ABSTRACT. The thyroid status of 106 adults with Down's syndrome was assessed. Six were previously diagnosed as hypothyroid and were already receiving thyroxine. A further 37 patients showed abnormal thyroid function. Biochemical evidence of hypothyroidism (T4 < SO nmol/1 and T.S.H.>4 mu/<) was found in one person. Six patients were found to have an unequivocally elevated T.S.H. but normal T4 (T4>50 nmol/l and T.S.H.>20 mu/1) and 29 were found to have a modest elevation of T.S.H. but normal T4 concentration (T4>50 nmol/1 and T.S.H. between 4 and 20 mu/l). There was one patient with milJ thyroloxicosis (T4= 180 nmol/1 and T.S.H.<0.1 mu/l). Clinical findings were of little use in making a diagnosis of hypothyroidism in this group of patients. A raised level of thyroid microsomal auto‐antibodies was found in about a third of the patients, this occurred more commonly in females and slightly more often in those with a raised thyroid stimulating hormone. The importance of this is discussed. Recommendations for regular biochemical screening are made.
This study aimed to investigate the effect of one intensive training session on the changes of beta-endorphin and serum cortisol levels of elite wrestlers. Methods: In this quasi-experimental research with one group and pretest-posttest design, 16 elite wrestlers within the age range of 18 to 25 years were purposefully and selected and they voluntarily participated in the research. The subjects performed one session of intensive exercise with the intensity of 85% to 90% of maximum heart rate. The blood samples (5 mL) were collected two times. First it was taken 30 minutes before the exercise and second blood sample was taken immediately after exercise by one expert and two physicians. The data were analyzed by paired-samples t-test using SPSS 17 and α value was set at 0.05. Results: There was a significant difference between beta-endorphin levels of elite wrestlers before and immediately after the exercise session (P=0.024). The serum cortisol level also increased significantly during the test (P=0.048). Conclusion: According to the findings of the study, beta-endorphin increase can make happy the athletes. Furthermore, the rise of cortisol level can increase the efficiency of immune system, boost the energy, maintain the body balance, and decrease the pain sensation.
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