Implementation of step-and-shoot intensity-modulated radiotherapy (IMRT) needs careful understanding of the accelerator start-up characteristic to ensure accurate and precise delivery of radiation dose to patient. The dosimetric characteristic of a Siemens Primus linear accelerator (LA) which delivers 6 and 18 MV x-rays at the dose rate of 300 and 500 monitor unit (MU) per minutes (min) respectively was studied under the condition of small MU ranging from 1 to 100. Dose monitor linearity was studied at different dose calibration parameter (D1_C0) by measuring ionization at 10 cm depth in a solid water phantom using a 0.6 cc ionization chamber. Monitor unit stability was studied from different intensity modulated (IM) groups comprising various combinations of MU per field and number of fields. Stability of beam flatness and symmetry was investigated under normal and IMRT mode for 20×20 cm2 field under small MU using a 2D Profiler kept isocentrically at 5 cm depth. Inter segment response was investigated form 1 to 10 MU by measuring the dose per MU from various IM groups, each consisting of four segments with inter-segment separation of 2 cm.In the range 1-4 MU, the dose linearity error was more than 5% (max −32% at 1 MU) for 6 MV x-rays at factory calibrated D1_C0 value of 6000. The dose linearity error was reduced to −10.95% at 1 MU, within −3% for 2 and 3 MU and ±1% for MU ≥4 when the D1_C0 was subsequently tuned at 4500. For 18 MV x-rays, the dose linearity error at factory calibrated D1_C0 value of 4400 was within ±1% for MU ≥3 with maximum of −13.5 observed at 1 MU. For both the beam energies and MU/field ≥4, the stability of monitor unit tested for different IM groups was within ±1% of the dose from the normal treatment field. This variation increases to −2.6% for 6 MV and −2.7% for 18 MV x-rays for 2 MU/field. No significant variation was observed in the stability of beam profile measured from normal and IMRT mode. The beam flatness was within 3% for 6 MV x-rays and more than 3% (Max 3.5%) for 18 MV x-rays at lesser irradiation time ≤3 MU. The beam stability improves with the increase in irradiation time. Both the beam energies show very good symmetry (≤2%) at all irradiation time.For all the three segment sizes studied, the nonlinearity was observed at smaller MU/segment in both the energies. When the MU/segment is ≥4, all segment size shows fairly linear relation with dose/MU. The smaller segment size shows larger nonlinearity at smaller MU/segment and become more linear at larger MU/segment. Based on our study, we conclude that the Primus LA from Siemens installed at our hospital is ideally suited for step-and-shoot IMRT preferably for radiation ON time ≥4MU per segment.
Conventional radiograph-based implant dosimetry fails to correlate the spatial dose distribution on patient anatomy with lack in dosimetry quality. Though these limitations are overcome in computed tomography (CT)-based dosimetry, it requires an algorithm which can reconstruct catheters on the multi-planner CT images. In the absence of such algorithm, we proposed a technique in which the implanted geometry and dose distribution generated from orthogonal radiograph were mapped onto the CT data using coordinate transformation method.Radiograph-based implant dosimetry was generated for five head and neck cancer patients on Plato Sunrise treatment planning system. Dosimetry was geometrically optimized on volume, and dose was prescribed according to the natural prescription dose. The final dose distribution was retrospectively mapped onto the CT data set of the same patients using coordinate transformation method, which was verified in a phantom prior to patient study. Dosimetric outcomes were evaluated qualitatively by visualizing isodose distribution on CT images and quantitatively using the dose volume indices, which includes coverage index (CI), external volume index (EI), relative dose homogeneity index (HI), overdose volume index (OI) and conformal index (COIN).The accuracy of coordinate transformation was within ±1 mm in phantom and ±2 mm in patients. Qualitative evaluation of dosimetry on the CT images shows reasonably good coverage of target at the expense of excessive normal tissue irradiation. The mean (SD) values of CI, EI and HI were estimated to be 0.81 (0.039), 0.55 (0.174) and 0.65 (0.074) respectively. The maximum OI estimated was 0.06 (mean 0.04, SD = 0.015). Finally, the COIN computed for each patient ranged from 0.4 to 0.61 (mean 0.52, SD = 0.078).The proposed technique is feasible and accurate to implement even for the most complicated implant geometry. It allows the physicist and physician to evaluate the plan both qualitatively and quantitatively. Dose volume indices derived from CT data set are useful for evaluating the implant and comparing different brachytherapy plans. COIN index is an important tool to assess the target coverage and sparing of normal tissues in brachytherapy.
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