In the present work, a simple synthetic route was reported for the preparation of azo oxime based Schiff base ligands and their Ni(II), Cu(II) and Zn(II) complexes. 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde oxime (HL 1 ) ligand was synthesized by condensing 2-hydroxy-3-methoxy-5-(phenyldiazenyl) benzaldehyde and hydroxyl amine hydrochloride in the molar ratio 1:1. Nitro and chloro substituted ligands, 2-hydroxy-3methoxy-5-((4-nitro-phenylazo)benzaldehyde oxime (HL 2 ) and 2-hydroxy-3-methoxy-5-(2-chloro-phenylazo)benzaldehyde oxime (HL 3 ) respectively, were also synthesized by the same method. The synthesized ligands were used to prepare metal complexes of Ni(II), Cu(II) and Zn(II) which were characterized by various analysis techniques. Ligands and their metal complexes were tested for their in vitro antibacterial and antioxidant activities. Ligands shows good antibacterial activity and it increases remarkebly after metal complexetion with MIC (Minimum inhibitory concentration) ranging from 3.90 μM/mL to 125 μM/mL for Zn(II) metal complexes over standard broad spectrum drug chloramphenicol having MIC 386 μM/mL against gram positive as well as gram negative bacteria. Synthesized ligands showing good antioxidant property which is comparable to that of natural antioxidant Ascorbic acid.[a] M. S. Kasare, Dr.
The neutral extractant, Cyanes-923 has been used for the extraction and separation of gallium(III), indium(III) and thallium(III) from acidic solution. These metal ions were found to be quantitatively extracted with Cyanex-923 in toluene in the pH range 4.5?5.5, 5.0?6.5 and 1.5?3.0 respectively, and from the organic phase they can be stripped with 2.0 mol dm-3 HNO3, 3.0 mol dm-3 HNO3 and 3.0 mol dm-3 HCl, respectively. The effect of pH equilibration period, diluents, diverse ions and stripping agents on the extraction of Ga(III), In(III) and Tl(III) has been studied. The stroichiometry of the extracted species of these metal ions was determined on the basis of the slope analysis method. The reaction proceed by solvation and the probable extracted species found were [MCl3. 3Cyanex-923]?[where M = Ga(III) or In(III)]?and [HTlCl4. 3Cyanex-923]. Based on these results a sequential procedure for the separation of Ga(III), In(III) and Tl(III) from each other was developed.
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