The spread of oncological diseases is currently one of the main problems in both humanitarian and veterinary medicine. Despite the high achievements of domestic and foreign scientists of modern veterinary medicine in the field of diagnosis, treatment and prevention of oncological processes, the number of cancer-affected animals is quite large and continues to grow steadily. Therefore, improving the complex of diagnostic studies for neoplasms among dogs and cats is one of the priority areas of veterinary medicine. The research was conducted on the basis of the veterinary clinic of the Center for Animal Beauty and Health "Zoostyle" IP Gorinsky V.I. (Volgograd) and the Department of "Morphology, Pathology of Animals and Biology" of the Saratov State Agrarian University. In the period from 2018 to 2021, 244 patients, including 127 dogs and 117 cats, were examined by an oncologist at the veterinary clinic of the Zoostyle Center for Animal Beauty and Health.All the animals belonged to residents of the city of Volgograd. When an animal was admitted to the clinic for an oncological appointment, animals with any visual signs of a neoplasm in the projection of the breast were selected for research. As a result of the physical examination, based on the results of laboratory, X-ray and ultrasound examinations, MR tomography, it was found that breast tumors (OMJ) are more common among dogs and cats. In the population of dogs, OMH accounted for 33.8% (n=43) and 62.4% (n=73) of all cases of oncological pathology in cats. Depending on the gender, breast neoplasia was observed in females - 100%, in cats, females accounted for 89%, and males - 11%. The results obtained indicate that the introduction of a complex of modern high-tech diagnostic methods into veterinary oncology practice is a key element that significantly affects the prospects for providing specialized care and prognosis.
Biocompatible nanoparticles attract the attention of researchers as a means of correcting a wide range of diseases. The carbonbased nanostructure, fullerene C60, is one of the most promising compounds. However, the use of compounds based on fullerene nanoparticles remains limited. Therefore, the development of domestic innovative medicinal compounds based on fullerenecontaining nanoparticles is one of the priority areas of veterinary medicine. The research was carried out in the laboratory of the Department of "Morphology, Pathology of Animals and Biology" of the Saratov State Agrarian University named after N.I. Vavilov. The first group served as a control. An aqueous solution of fullerene C60 was administered at a dose of 1 ml per (DV 5 mg / kg) 1 kg of body weight (group 2 animals). A compound based on an aqueous solution of fullerene C60 was also introduced, including an aqueous solution of fullerene C60, Lcarnosine and succinic acid in the following ratio of components, wt. / mg: an aqueous solution of fullerene C60 stabilized with pluronic F-127– - 5 ml (5 mg by DV), Lcarnosine -50 mg, succinic acid - 50 mg per 1 kg of body weight (group 3). The studied compounds were administered intramuscularly, once. Glycerin loading was carried out 24 hours after the introduction of the studied compounds. It was found that aqueous solutions of fullerene C60 have a distinct effect on carbohydrate metabolism in the body of white rats. The initial blood glucose level in animals of all groups turned out to be approximately at the same level, but the highest rate of gluconeogenesis was found in animals of group 2. As for the gluconeogenic function of the liver, in animals after the introduction of aqueous solutions of fullerene C60, the increase in newly formed glucose and the rate of gluconeogenesis significantly exceeded the control values. The results obtained indicate a failure in glucose metabolism after the introduction of aqueous solutions of fullerenes.
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