Primary sinonasal neuroendocrine carcinoma (SNEC) is a rare aggressive sinonasal malignancy which typically occurs in the ethmoidal bone or sinuses, with a slight male preponderance. No risk factors have been identified. With a very few reported cases. Most patients present in advanced stages due to the lack of significant symptoms. Nomenclature has been ambiguous, but SNECs can be classified as well-, moderately- or poorly differentiated. Its treatment is not well established. We report the case of a large cell neuroendocrine carcinoma (LCNEC) in a 34 years old patient presented the occurrence of a right epistaxis. The beginning of the symptomatology goes back to 1 year before, with right nasal obstruction of progressive onset, associated with right epistaxis and bloody rhinorrhea with right chronic eye watering. Nasosinusal MRI shows a right nasal mass enhanced strongly after injection of gadolinium, extension to contralateral ethmoidal cells with orbital bone lysis and cribriform plate of the Ethmoid bone. The Histopathologic analysis of the mass biopsy showed a poorly differentiated carcinomatous tumor proliferation with positive neuroendocrine markers. The multidisciplinary decision taken was the treatment by chemotherapy before surgery.
Patients with pheochromocytoma are typically symptomatic. Hypertension is the most common sign of pheochromocytoma. Clinically silent giant pheochromocytoma is a rare adrenal disease; complete resection is the only curative treatment. Due to the serious surgical risk, successful resection is very difficult. We report a case of 70-year-old- female with giant pheochromocytoma, which was successfully resected. There were no intraoperative and postoperative complications. We analyze and report our experience.
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