Prolonged release drug delivery system of stavudine was made by ionotropic gelation and polyelectrolyte complexation technique. Cross-linking reinforced chitosan-gellan complex beads were prepared by gelation of anionic gellan gum, the primary polymer, with oppositely charged counter ion to form beads which were further complexed with chitosan as a polyelectrolyte. The effect of this polymer on release profile of drug was studied. Beads without chitosan complexation were also made. The reaction of chitosan-gellan complex dominates the formation of skin layer on the surface of beads. Stavudine an antiretroviral drug was selected as novel drug for the experiment. The final formulations were subjected to in vitro evaluation and several characterization studies. Batches with gellan gum shows Higuchi model, while chitosan-gellan shows zero order release. All the batches with copolymer showed sustained the drug release more than 12 h, whereas with gellan gum alone showed up to 10 h. Batches with chitosan showed maximum drug encapsulation efficiency.

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The present study sought to develop and evaluate spray-dried microspheres of chitosan and xanthan gum for controlled release of ramipril, a widely used antihypertensive drug. The prepared microspheres were characterized by particle size analysis, scanning electron microscopic studies, differential scanning calorimetric analysis, Fourier transform infrared spectroscopy analysis, X-ray diffraction studies, drug entrapment efficiency, and in-vitro drug release study. The prepared microspheres were spherical in shape and freely flowing. The size of the microspheres was in the range of 25.7 to 47.4 µm and the drug entrapment efficiency was in the range of 74.68% to 90.44%. TheDSC analysis and X-ray diffraction studies indicated that the drug was uniformly dispersed in amorphous state in the microspheres. The in-vitro drug release indicated that the spray-dried microspheres prepared with chitosan alone were not suitable for controlled released delivery of drug as maximum amount of drug was released within 5 hrs. Whereas microspheres prepared by xanthan gum released small amount of drug within 5 hrs and more amount of drug was controlled released that fit the therapeutic needs. Drug release mechanism followed non-Fickian transport. These suggest the formulation potential of chitosan and xanthan gum for spray-dried microspheres for controlled release of ramipril

The aim of this research was to develop and evaluate liquisolid compacts of Voriconazole a BCS class II drug. The series of formulations containing Voriconazole drug were formulated by using aerosil a colloidal silicone dioxide and avicel PH microcrystalline cellulose in different ratios by using suitable solvent. Solubility studies were performed in propylene glycol and polyethylene glycol (PEG-200, 400, 600) for the choice of the best non volatile liquid to dissolve Voriconazole. On the basis of the solubility data PEG 600 was chosen as a good solvent for the Voriconazole. Voriconazole was dissolved in solvent PEG 600 for the preparation of solution of drug. Formulated compacts were evaluated for all post compression parameters and the in-vitro drug release study was carried out. All the formulations have shown a very good drug release in  15 min except compressibility problems due to higher loading factor of liquid vehicle for the formulations. The selected formulation FV10 containing 30% of drug solution has  shown good drug release of 100.2.% in 15  min compared to dissolution of  pure drug and marketed tablet which shown 58.5.5%  and 70..6 % respectively.No interactions were found  between drug and polymers in FITR as well as DSC. XRD of selected formulation shows that drug present in the formulation is in amorphous form. Keywords: Voriconazole HCl, Avicel PH, Aerosil 200, Poly-Ethylene Glycol 600, liquisolid compacts.