Die aus den Acetylhydrazinen (I) durch Umsetzung mit Arylisothiocyanaten (II) hergestellten Thiosemicarbazide (III) lassen sich mit Quecksilberoxid zu Oxadiazolen (IV), mit Schwefelsäure zu Thiadiazolen (V) cyclisieren.
Reaction of the hydrazides (I) with the isothiocyanates (II) in sodium hydroxide solution produces the triazoles (III), while the same reaction in methanol yields the thiosemicarbazides (IV).
Synthesis and Antifungal Activity of Some 1,4-Disubstituted Thiosemicarbazides, 2,5-Disubstituted 1,3,4-Thiadiazoles, and 3,4-Disubstituted 5-Mercapto-1,2,4-triazoles.-The thiosemicarbazides (III) are prepared by refluxing a mixture of the hydrazides (I) and the aryl isothiocyanates (II) in methanol. Cyclization of (III) yields the 1,3,4-thiadiazoles (IV). The 1,2,4-Triazoles (V) are synthesized by treatment of the hydrazides (I) and the aryl isothiocyanates (II) with sodium hydroxide. Some of the products have antifungtal activity against Aspergillus niger and Helminthosporium oryzae. -(MISHRA, R. K.; TEWARI, R. K.; SRIVASTAVA, S. K.; BAHEL, S. C.; J. Indian Chem. Soc. 68 (1991) 2, 110-112;
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