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A REVIEW of 31 cases with necropsy which presented a clinical picture of transverse or diffuse "myelitis" revealed the striking fact that in 9 the lesion of the cord was a myelomalacia secondary to malformation of the vessels of the spinal cord. These nine cases, in five of which the lesions were diffuse and in four focal, are considered in the present report.Knowledge of such malformations is not new. The presence of vascular abnormalities has been noted by neurosurgeons in certain cases of spinal compression. Numerous reports of this association have appeared in the literature.1 Congenital malformations may also result in a myelitic picture of a special type, and this was first described by Foix and Alajouanine 2 as my\l=e'\liten\l=e'\crotiquesubaigue.The clinical characteristics given by these authors were of progressive paraplegia, at first spastic, then flaccid with atrophy, the process advancing slowly upward in the spinal cord. A short time later, dissociated sensory disturbances appeared, with sparing of touch sense at first but with the dissociation becoming total afterward and progressing upward. The cerebrospinal fluid contained a large amount of protein, with albuminocytologic dissociation. Death occurred in one to three years. Anatomic findings included a predominantly central necrosis of the lower part of the spinal cord, pure at lumbosacral levels, mixed with hemorrhages in the lower dorsal level, and ending in the midthoracic region. Associated with this necrosis, an intense endo-meso-vascularite was encountered, as well as an increased number of leptomeningeal vessels, which were enlarged, and were thick in the lumbar region but thinner above. The intramedullary vessels were also altered, being more From the

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Patris M, Agussol P, Alby JM, et al. A double-blind multicentre comparison of remoxipride, at two dose levels, and haloperidol. Acta Psychiatr Scand 1990; 82 (Supp1.358): 78-82.Abstract: A total of 186 patients who met the DSM-I11 criteria for schizophrenia were admitted to a double-blind randomized multicentre trial in which the efficacy and safety of remoxipride at two dose levels was compared with those of haloperidol. Over a period of six weeks the patients received remoxipride 100-300 mg/day (n=60), remoxipride 200-600 mg/day (n=61), or haloperidol 10-30 mglday (n=64). There was no significant difference between the three treated groups with regard to the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) scores obtained. Remoxipride, at both dosage ranges used, thus had comparable therapeutic efficacy to that of haloperidol. In contrast, extrapyramidal symptoms occurred significantly more frequently in the group treated with haloperidol. Laboratory tests and cardiovascular investigations showed no specific drug effect in any of the treated patients. Remoxipride is thus effective in acute treatment of schizophrenia at both dosage levels and has an advantage over haloperidol in neurological acceptability.Remoxipride is a substituted benzamide, which in-vitro

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An intracranial hypertension was found at autopsy to be due to a limbic infiltrating glioma. A cortical temporal biopsy had been done 14 months before, whose ultrastructural results are reported. Membranous whorls, made of two dense membranes with a variable separative space are seen around neurones, dendrites, axons, synapses and oligoglial cells; they derived from astrocytes and are joined by 2 types of cell junctions: gap-junctions and puncta adherentia. Relations between reactive and tumoral gliosis are discussed.

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