Conclusions: Real-time VCI-A with a 4D electronic probe is an effective tool for imaging the fetal extremities in mid-trimester examinations and carries some advantages over conventional 2D sonography. Objectives: To assess the development in the diagnosis and outcome of prenatally diagnosed fetuses with talipes equinovarus (TEV). Methods: A retrospective evaluation of diagnosis, management and follow-up of cases of prenatally diagnosed fetuses with TEV in the years [2007][2008][2009][2010][2011][2012][2013][2014][2015][2016]. Results: We diagnosed 114 fetuses with TEV in our centre. The average age of women was 32.4 years. We found the outcome in case of 80 fetuses. There was a total of 48 fetuses with isolated TEV and of that, 32 fetuses were with associated anomalies. None of these malformations have been diagnosed in the first trimester. The diagnosis was set between 16 -32 weeks, with an average of 20.2 weeks. The ratio of male:female representation was 2.4:1. A positive family history of TEV has been present in 24 (30%) cases. Chromosomal aberration was diagnosed in 11 (14%) fetuses, false-positive diagnosis in 8 fetuses (10%). In 42 (75%) children, the conservative treatment has been followed up by surgical treatment, of that in 17 (30%) repeatedly. In the group of 48 fetuses with isolated TEV were diagnosed 29 fetuses with unilateral and 19 with bilateral TEV. One fetus died in utero. 47 children were born alive. In the case of isolated TEV there were postnatally diagnosed neurodevelopmental or structural abnormalities in 6 (13%) children. We diagnosed 32 fetuses with associated anomalies with TEV, with that 81% had the bilateral. In the group with associated congenital defect 22 (27.5%) women terminated the pregnancy. 9 children were born alive. Conclusions: In the case of isolated bilateral TEV, associated anomalies (T18, T21, Becker muscular dystrophy, FRAXA syndrome) were detected using AMC. Prenatally undiagnosed anomalies were VSD, anal atresia, hypotonia, Freeman Sheldon syndrome. AMC was used in case of 85 (75%) fetuses with TEV. Because of the possible associated anomalies, which cannot be diagnosed by ultrasound examination, the invasive procedure should be recommended to patients, especially in the case of bilateral TEV. EP07.10 EP08: FETAL STRUCTURAL ABNORMALITIES IEP08.01 Hemodynamic indices of mother-placenta-fetus system in pregnant at high risk of intrauterine infection L. Vygivska, E. Radzishevskaya, V. Kalnytska Kharkiv National Medical University, Kharkiv, UkraineObjectives: To assess hemodynamic criteria of mother-placenta-fetus system in pregnant at high risk of intrauterine fetal infection (IFI). Methods: The study involved Doppler examination of hemodynamics in mother-placenta-fetus system in 93 pregnant at high risk of IFI development with placental dysfunction. Screening for urogenital infections detected monoinfections in 26.9% and mixed bacterial-viral infections in 73.1% of patients. Blood flow velocity was studied in uterine arteries, umbilical artery and medial cerebral arte...
Oral poster abstracts the coronal plane in multiplanar aquisition to exclude the presence of residual septum. Results: The septum length was decreased after surgery. In 45% patients a residual septum tissue between 5 mm and 10 mm was observed and in 50% of the patients the residual septum was more than 10 mm. Among patients with residual septum more than 10 mm, 50% miscarried again. Among patients with residual septum between 5 and 10 mm 46% had full term pregnancy and 15% had preterm deliveries, 6% had abortion. Conclusions: Three dimensional transvaginal ultrasound should be the first choice technique to quantify uterine residual septa after hysteroscopic methroplasty. Objectives: The incidence of defective development of the Müller duct in population is stated in the range 0.1-3%. In women with reproductive disorders the occurrence of the aforesaid is higher cca 4% and in the cases of repetitive loss of pregnancy it ranges between 3-38%. The study examines the incidence of previously undiagnosed inborn developmental defects of uterus in women with reproductive disorders. Methods: The medical checks were carried out within 1 st consultation in the IVF centre. Uterus and ovaries were shown in 3D; the ultrasound examinations were performed transvaginally by 4 trained personnel on VOLUSON E8 (GE Medical Systems). In I -XII 2010 794 women of the average age of 32.2 were examined. Classification of uterus malformations was executed in concordance with American Fertility Society (1988). Hysteroscopy or laparoscopy followed in the case of anomaly findings. OP19.06 Results:The results are summarized in the table. Conclusions: Diagnosis of uterus malformations with the help of 3D ultrasound is quick, non-invasive, easily performed and painless. In our set we have diagnosed 11.8% previously unrecognized uterus malformations, out of which 2.5% were critical for successful reproduction.OP19.06: Table Uterus OP19.08The effect of ovulation on standardised fractional moving blood volume (sFMBV) of the subendometrium S. Sur, J. Elangovane, J. Clewes, B. Campbell, N. Raine-Fenning School of Clinical Sciences, Division of Human Development, University of Nottingham, Nottingham, United KingdomObjectives: Current measures of FMBV are not standardised for attenuation. We introduce a novel technique which does this and assess its reliability. We investigate the effect of ovuln on subendometrial sFMBV Hypothesis: subendometrial vascular indices fall in mid luteal phase. Methods: 154 women with reg cycles prospectively recruited. TV USS performed in late follicular and midluteal phases. 3D dataset of uterus incorporating uterine vessels acquired using power Doppler angiography. Using VOCAL (9 • ) endometrial volume measured.Histogram facility used to measure vascularity indices in 3, 5 and 7 mm subendometrial shells. Using VOCAL, a small sphere was placed within brightest part of uterine artery level with endometrium where VI = 100%. Related FI was the standardising factor. Vascular indices were divided by this factor to give sFMB...
Electronic poster abstractsConclusion: The father and probably the oocyte donor are carriers of the mutation in the ZMPSTE24 gene, with a repeat risk of 25% for the frozen embryos which can be examined by preimplantation genetic diagnosis. Prenatal diagnosis of RD has not been described previously, but is possible through amniocentesis. Visualisation of the fetal axial BPD plane including the choroid plexus (CP) with the so-called 'butterfly sign' in the lateral ventricles has proven to be one of the most sensitive first-trimester sign for structural cerebral abnormalities. While abnormal shape with fusion of the CP is associated with holoprosencephaly, ratios of CP and the ventricle diameters as well as CP and ventricle area under the 5th percentile have been postulated as an early sign of ventriculomegaly. Beyond that CP asymmetries have been considered as an early physiological sign of laterality. However, there are only limited data available about the clinical relevance of CP asymmetries. Hemimegalencephaly (HME) is an extremely rare malformation of the brain. It is characterised by an enlarged cerebral hemisphere with or without signs of cortical developmental malformations. In the reported case a 25-year old patient -G1, P0 -was initially referred at 13+3 weeks gestation. Except a slight difference in CP size the early anomaly scan did not reveal any major structural abnormalities and resulted in an adjusted risk of 1: 4134 for Trisomy 21 and 1: 7622 for Trisomy 13/18, respectively. At the time of the second trimester anomaly scan (23+2 gestational weeks) the fetus was affected by macrocephaly as wells as abnormal growth and cortical development of the right hemisphere with unilateral ventriculomegaly leading to midline deviation and compression of the left hemisphere suspecting HME. The combination of 2D and 3D ultrasound as well as MRI confirmed the diagnosis of hemimegalencephaly. To conclude, this case expands on previous studies suggesting that CP size asymmetry could also be an early sign for abnormal laterality. We report the diagnostic imaging and prenatal management. Obstruction of the upper respiratory tract (trachea/larynx) occurs due to atresia, stenosis or the presence of a membrane. The prenatal diagnosis is relatively simple. It presents with very significant and characteristic ultrasound features. The prognosis is bad presenting a very high mortality rate. We report a case of prenatal diagnosis of a suspected esophageal atresia and postnatal diagnosis of laryngeal atresia. EP10: HEAD AND NECKEP10 EP10.02This gravid woman did not present any major morphological anomalies at mid-trimester scan. She was referred to our unit at 28 weeks gestation due to non-visualisation of the gastric chamber and polyhydramnios. A small gastric chamber and severe polyhydramnios were confirmed. The suspected diagnosis of esophageal atresia with tracheoesophageal fistula was suspected. Two amnioreductions were performed due to maternal discomfort. Caesarean section was performed with 40 weeks + 3 for fetal dist...
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