146s S13. Computers in patient management and quality control Olanzapine and Sertindole were investigated very carefully under this aspect. For these compounds a better efficacy on negative symptoms compared to placebo and to Haloperidole could be demonstrated. In addition it was shown, that most parts of the better effect was a dual-effect on the negative symptoms, not explainable via the effect on positive symptoms, better extrapyramidal tolerability or depressive symptoms.
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