Precise viscosity data for aqueous binary mixtures of ethylene glycol (EG), 2-methoxyethanol (ME), and 1,2-dimethoxyethane (DME) at different mole fractions and at various temperatures are presented. EG behaves as a structure breaker showing negative deviation in viscosity–composition curve. Hydrophobic solutes ME and DME showed typical maximum in viscosity–composition curve in water rich region; attributed to the existence of “microheterogeniety” in these mixtures.
The substituted thiosemicarbazides 1-15, synthesized by the condensation of substituted 5-chloro-diphenylamine-2-carboxylic acid hydrazides with appropriate arylisothiocyanates, have been tested for their antiviral activity against the plant virus, sunnhemp rosette virus, in vitro as well as in vivo and against the animal virus, ranikhet disease virus, in a stationary culture of chorioallantoic membranes of chick embryo. The majority of these compounds showed significant antiviral activity against both viruses. The structure-activity relationships have further been studied and are discussed.
Synthese einiger neuer snbstituierter Tbiosemicarbazide als potentielle mtivirale AgentienDie substituierten Thiosemicarbazide 1-15, synthetisiert durch Kondensation substituierter 5-Chlordiphenylamin-2-carbonsaurehydrazide mit geeigneten Arylisothiocyanaten, wurden auf ihre Wirksamkeit gegen ein pflanzenpathogenes Virus, Sunnhemp-rosette-Virus, sowohl in vitro als auch in vivo und gegen ein tierpathogenes Virus, Ranikhet-disease-Virus, in einer stationaren Kultur der Chorionallantoismembran des Hiihnerembryos gepriift. Die meisten dieser Verbindungen zeigen signifikante antivirale Wirkswnkeit gegen beide Viren. Die Struktur-Aktivitatsbeziehungen wurden studiert und diskutiert.Diphenylamine-2-carboxylic acid derivatives have been reported to exhibit diverse biological properties such as anthelminthic'), antiba~terial~.~); antifunga14) and antiviral5,@. Further, a large number of thiosemicarbazides have also been found to be remarkably antiba~terially'.~), antifungally9) and antivirally"*") active. Our interest was thus arisen to synthesize the title compounds having both the diphenylamine-2-carboxylic acid nucleus and the thiosemicarbazide group and to see if these would be effective as antiviral agents.Substituted 5-chlorodiphenylamine-2-carboxylic acids, prepared by the Ullmann reaction of 2,4-dichlorobenzoic acid with substituted aromatic amines in presence of anhydrous K2CO3, Cu powder and amyl alcohol, were converted into methylesters by refluxing with thionyl chloride and absol. methanol. The methyl esters on reaction with +) Adress: 559K/22CHH,
Substituted 2-phenylbenzoxazinones or 2-methylacetanthranils were condensed with substituted 4-aminodiphenyl ethers to furnish the quinazolinones 3. Most of the compounds were screened for their inhibitory effects on mono-amine oxidase and acetylcholinesterase of rat brain homogenate. All compounds were also evaluated for their antimicrobial activity.
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