In recent years industrialization caused, magnificent leaps to high profitable growth of pharmaceutical industries, however, simultaneously it has given rise to environmental pollution. Pharmaceutical processes like extraction, purification, formulation etc. generates huge volume of wastewater with high COD, biological oxygen demand, auxiliary chemicals, and different pharmaceuticals substance or their metabolites in the active or inactive form imparting intensive color, which necessitates its proper treatment before being discharged. This study focuses on the feasibility analysis of utilization of ultrasound cavitation assisted with persulfate oxidation approach for the treatment of such complex effluent. Process parameters like pH, amplitude intensity, oxidant dosage was optimized for COD removal applying response surface methodology-based Box Behnken design. The optimum value observed for pH, amplitude intensity, oxidant dosage is 5, 20%, 100 mg/L respectively with 39.5% removal of COD and 6.5% removal of TOC in 60 min of fixed processing time. Study confirms that acombination of ultrasound cavitation and persulfate is a viable option for the treatment of pharmaceutical wastewater than individual treatment and it can be used as an intensification technique in existing treatment plants for achieving maximum COD removal.
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