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This work was done to identify some of the plants used in the treatment of malaria in Uganda and to investigate their efficacy in the in-vifro assays. Plumbago zeylenica and Cryptolepis sanguinolenm showetl marked activity on the chloroquine resistant and chloroquine sensitive strains of Plnsmorlium falcipnrum. Plumbagin, a quinone, mas isolated from Plumbflgo zeylenicn, ant1 fount1 to have antimalarial activity with ICSo of 178 nglml on cllloroquine sensitive and 188 nglml on chloroquine resistant strains. Cytotoxicity assays on KB cell lines indicated that the extract was selective for Plrc~morlicinz fnlciyarunr. The Selective Index was 5 in both strains of Plmmodium frrlciparunt. It was concluded that some of the plants used for malaria contain compounds with antimalarial activity, which can be useful leads for the development of new antimalarial drugs.