The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p < 0.05) in body weight (380 ± 0.34), total fat (72 ± 0.8), fat percentage (17 ± 0.07) and fat free mass (165 ± 0.02). Reduction (p < 0.05) in insulin resistance (5.20 ± 0.03), lipid profile (TC 120 ± 0.05; TG 160 ± 0.24; HDL 38 ± 0.03), liver lipid peroxidation (0.7 ± 0.01), hepatic enzyme markers (AST 82 ± 0.06; ALT 78 ± 0.34; ALP 42 ± 0.22), and hepatic steatosis by increasing liver antioxidant potential (CAT 1.4 ± 0.30; GSH 1.04 ± 0.04; SOD 0.82 ± 0.22) with normal hepatic triglycerides (15 ± 0.02) and glycogen (0.022 ± 0.15) contents and also showed normal liver size, less accumulation of lipid droplets with only a few congestion. It is concluded that the increased intestinal S. cerevisiae yeast can switch anti-obesity, antidiabetic, antioxidative stress, antioxidant and anti-hepatosteatosis effect. This study results will have significant implications for treatment of NAFLD.
Aim:Ethnomedicinal studies on medicinal plants used by Yanadi tribe of Chandragiri reserve forest area are documented during the period of 2014-2015. The study is mainly focused on medicinal importance of plants used by Yanadi tribe to treat various ailments.Materials and Methods:The information collected on treated ailments, part used, preparation, combination, and addition of ingredients to prepare herbal medicines with the help of standard questionnaire.Results:During the study, 53 types of ailments were treated using 48 medicinal plants belongs to 26 families were documented. Among the medicinal plants, shrubs (15) were most using life form of plants for the preparation of herbal medicines. Leaf part (40%), paste form (33%), and oral administration (63%) of herbal medicines were most preferable. The documented ethnomedicinal importance of this tribe was cross-checked with Dr. Duke’s Phytochemical and Ethnobotanical database shows most of the plants were correlated with this database.Conclusion:There is no record of traditional medicinal knowledge of these villages so far, hence the present study is aimed to document the information on medicinal plants used by Yanadi tribe in Chandragiri reserve forest area. The correlation of ethnomedicinal uses with Dr. Duke’s Phytochemical and Ethnobotanical database clearly indicates the high medicinal significance of claimed data of this Yanadi tribe.
Aim:This study aimed to document the traditional knowledge of medicinal plants and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Chittoor district, Andhra Pradesh, India.Materials and Methods:The study was mainly focused on documentation of medicinal plants used by Yanadi tribe to treat different diseases with a standard questionnaire. These plants were cross-checked in Dr. Dukes Database and available literature to know the significance of this tribe on medicinal knowledge. Among the documented plants, T. populnea was selected for antimicrobial activity with disc diffusion assay.Results:Among the documented medicinal plants, herbs were the most utilized plants, followed by leaf part of the plants; paste form of medicinal preparation was the dominant one among the mode of preparations and oral administration was generally followed by this tribe. When checked these plants in Dr. Duke’s Phytochemical and Ethnobotanical Database most of the medicinal plants were matched at least one medicinal use and most of them were correlated with existing literature. In antimicrobial activity, the microbial pathogens Klebsiella pneumonia among bacteria and Rhizopus arrhizus among fungi were most susceptible to methanol extract of T. populnea.Conclusion:From this study, we conclude that the preparation and dosage of the medicines by Yanadi tribe of this area is unique and the correlation of medicinal data with Duke’s Database and existing literature reveals high medicinal significance of claimed data of this tribe and potential inhibitory activity of T. populnea could be studied further to isolate effective antimicrobial agents.
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