In water and in the presence of 1 mol % of Poly(ethylene glycol)-bounded sulfonic acid, amines undergo smooth condensation with 2,5-hexadione at room temperature to afford the corresponding pyrroles in good to excellent yields. The sole products were solidified as the reaction proceeded and separated by simple filtration. In addition, bispyrroles were synthesized in excellent yields via this eco-friendly protocol. The method is easy, simple, cost-effective, chemoselective, and environmentally benign that introduces a beautiful example of click chemistry in water.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.