The article is dedicated to the issues of increasing the competitiveness of Russian regions in the context of updating innovative types of development. The necessity of a differentiated approach to enhancing innovation at the regional level in accordance with the principles of "smart specialization" is well established. The basic requirements for the selection of priorities and directions of development of domestic regions are determined, taking into account the existing production potential and local competencies. Using cluster analysis, a typology of the Russian regions was carried out according to the degree of development of systemic elements of the knowledge economy and their grouping by the potential for creating and using new knowledge and technologies. Mechanisms are proposed for supporting innovation in the regions according to the profile of cluster groups. It is argued that the use of variable tools in the field of innovative development in accordance with the types of regions will contribute to increasing the competitiveness of regional economies and the formation of comparative competitive advantages.
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