Curcumin has diverse therapeutic effects, such as anti-inflammatory, anti-oxidant, anti-cancer, and antimicrobial activities. The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception. However, very little is known about the effects of curcumin on nociception. In the present study, we investigated whether the anti-nociceptive effects of curcumin are mediated via TRPV1 by using nociceptive behavioral studies and in vitro whole-cell patch-clamp recordings in the trigeminal system. Subcutaneous injection of capsaicin in the vibrissa pad area of rats induced thermal hyperalgesia. Intraperitoneally administered curcumin blocked capsaicin-induced thermal hyperalgesia in a dose-dependent manner. Whereas curcumin reduced capsaicin-induced currents in a dose-dependent manner in both trigeminal ganglion neurons and TRPV1-expressing HEK 293 cells, curcumin did not affect heat-induced TRPV1 currents. Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity.
Short oral presentation abstracts distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonray dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Receiver operating characteristic (ROC), survival (Kaplan Meier) and logistic regression analyses were performed to evaluate the contribution of weight discordance to neonatal morbidity. Results: A total of 940 twin pregnancies were included. Logistic regression analysis found that BW discordance (OR:1.2, 95% CI 1.1-1.4), EFW discordance (OR:0.45, 95% CI 0.38-0.53) and gestational age (OR:0.47, 95% CI 0.41-0.54), but not chorionicity (p = 0.24) or individual fetal size percentile (p = 0.64), were independently associated with neonatal morbidity. BW discordance of 29.6% had the highest AUC for the prediction of neonatal morbidity (BW AUC = 0.81; 95% CI:0.78-0.83), while an EFW discordance of 34% had the highest AUC (BW AUC = 0.77; 95% CI:0.66-0.91). Neither test, birthweight discordance or EFW discordance, was superior in its predictive accuracy (p = 0.71). Conclusions: BW discordance and EFW discordance are associated not only with perinatal mortality but also with neonatal morbidity in twin pregnancies born late preterm and at term. Objectives: To determine if ultrasound-indicated cerclage in multiple gestations is associated with the increased risk of adverse pregnancy outcomes Methods: This retrospective study included consecutive pregnant women with multiple gestations who were diagnosed as short cervix before 26 weeks of gestation and delivered at Seoul National University Hospital between 2000 and 2012. The study population consisted of cases who underwent ultrasound-indicated cerclage (C group, N=32) and those with expectant management (E group, N=13). Short cervical length was defined as less than 2.0cm. Cerclage operation was performed with the modified Shirodkar technique. While physical activity was not restricted in C group, patients in E group were recommended with limited activity. Results: C group consisted of 21 twin and 11 triplet pregnancies and E group included 9 twin, 3 triplet, and 1 quadruplet pregnancies. The median cervical length of the C group and E group at the time of diagnosis of short cervix and/or cerclage operation was 1.03cm and 1.25cm, respectively. C group had a lower median gestational age at the diagnosis of short cervix and/or cerclage operation (22.1 weeks vs. 23.1 weeks, p = 0.033) and a higher rate of funneling (89.7% vs. 53.8%, p = 0.016) than E group. Although gestational age at birth was not significantly different (median 35.0 weeks vs. median 34.3 weeks), diagnosis-to-delivery interval tended to be higher in C group than in E group (median 93 days vs. median 78 days, p = 0.064) and C group tended to have a lower rate of preterm birth before 32 weeks than E group (18.8% vs. 46.2%, p = 0.076). Conclusions: Cerclage operation in pregnant women with multiple gestation and short cervix was not associ...
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