The aim of this study was to examine the effects of orally administered simvastatin on the bone healing process in stroke-prone spontaneously hypertensive rat. Twenty-week-old female stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY) as a control were used. Bone defects were created in the femur of each rat. From the first day following surgery, half of each of the WKY and SHRSP rats were orally administered simvastatin (10 mg/kg/day). The WKY and SHRSP rats were each divided into experimental groups: 1) WKY simvastatin administration group (WKY-S), 2) WKY control group (WKY-C), 3) SHRSP simvastatin administration group (SHR-S), and 4) SHRSP control group (SHR-C). Experimental periods were set at 1, 2 and 4 weeks after surgery. After each experimental period, the animals were sacrificed. Radiographic analysis and histologic and histomorphometric examinations and immunohistochemical staining for BMP-2 were performed on the harvested samples. The data were statistically analyzed. The radiological analysis and histomorphometry parameters showed that the amount of newly formed bone in the trabecular bone area and cortical bone area increased significantly in the WKY-S group compared to that in the WKY-C group at 2 weeks. In addition, a positive immune reaction with BMP-2 was seen in osteoblasts located on the surface of newly formed bone and the outer periosteum around the marginal area of existing bone in WKY-S. In contrast, in both SHR-S and SHR-C 4 weeks after surgery, no differences in bone formation in the trabecular bone area and cortical bone area were recognized as being based on simvastatin administration. In addition, in the expression of BMP-2, there was no significant difference between the presence and absence of simvastatin administration. The oral administration of simvastatin under our experimental conditions had a facilitating effect on bone formation in WKY rats, whereas no effect was recognized in SHRSP rats.
Many studies have investigated the relationship between periodontal disease and the onset of peri-implantitis. It is important to devise practical measures for preventing the development of peri-implantitis in patients with periodontal disease if the success of implant treatment is to be secured. Here, we report the role of the superstructure in two cases of implant treatment in patients with severe periodontal disease. Both patients had severe periodontitis and underwent implant treatment after improving the state of the disease, thereby ensuring that the implant superstructure could be maintained. Both cases remained stable after implant treatment. The results indicate that proper periodontal treatment prior to implant treatment leads to long-term success. In addition, it is necessary to use an implant superstructure that reduces plaque accumulation in preventing peri-implantitis.
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