The patient, a 66-year-old woman, had been receiving conservative treatment for mucosal prolapse syndrome (MPS) for over 10 years. However, as the stenosis of the rectum was becoming worse, we decided to perform operation. Although repeated biopsies showed no evidence of malignancy, we could still not fully exclude the possibility of rectal cancer. Therefore, we performed low anterior resection (LAR). We also performed ileostomy, because of the high-risk of suture failure in view of a past history of ischemic colitis. After confirmation of the absence of recurrence of the MPS recurrence by colonoscopy, ileostomy closure was performed after 6 months.The patient developed recurrence of MPS despite receiving conservative therapy. LAR may contribute to provisional improvement and provide a histopathological diagnosis, but it does not represent radical treatment for MPS. Conservative treatment for MPS is required even after LAR.
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