1 The anti-hypertensive effects and safety of labetalol have been evaluated in multicentre clinical trials in Japan based on unified study protocols. The results of three studies are reported. 2 A total of 178 patients with essential hypertension were treated with labetalol for 12 weeks, 127 of them with labetalol alone (monotherapy) and the other 51 with labetalol plus diuretics (combined therapy). 3 Satisfactory antihypertensive effects were achieved in 76 of the 119 assessable patients in the monotherapy group and 25 of the 49 in the combined therapy group. The mean daily doses of labetalol were 329 mg in the monotherapy group and 374 mg in the combined therapy group.Seven patients (six in the monotherapy group; one in the combined therapy group) were withdrawn from the trials due to side-effects. 4 Sixty-one patients with hypertension were treated with labetalol alone or combined with diuretics for 6 months or longer. In most of these patients, good blood pressure control was achieved. No patients had to discontinue the treatment due to side-effects. The mean daily doses of labetalol were stabilised in and after week 8 of the treatment at an average of 260 mg in the monotherapy and 450 mg in the combined therapy. Tolerance to the anti-hypertensive effect did not develop. 5 Thirty patients with phaeochromocytoma were treated with labetalol and good blood pressure control was achieved in 21 of them. The effects of labetalol were better in patients with predominantly adrenaline-secreting tumours, and better in patients with sustained hypertensive type than in those with paroxysmal hypertensive type.
SynopsisAldosterone in 2 ml of plasma was determined by radioimmunoassay. A small modified 10 ml pipette column of LH-20 (0.8 x 15 cm) was used for separation and 1,4diaminoanthraquinone was employed as a marker dye. The application of the small modified column and the marker dye made the separation easy, rapid and accurate. The recovery, precision, accuracy, sensitivity and specificity of the method were satisfactory. This method was considered to be convenient enough for clinical use.
To evaluate the diagnostic usefulness of coronary angiography is the purpose of this presentation. Coronary angiography was performed both on pathological materials and clinical cases and compared with histopathological and other clinical findings.Method: Forty-nine hearts were studied by the method described by Schlesinger, and stereographic method was adopted. Frontal sections of 15cm. thickness were once more photographed by ultrasoft X ray.Other 169 hearts were studied by the method of Schonmacker. The contrastmedium was injected at first only into the left coronary arteries. Postero-anterior and left-anterior-oblique X-ray films were taken. Thereafter right coronary arteries were filled by contrast medium and photographed in the same positions. These experiments were made by Dr. K. Aoki under the supervision of prof. G.A. Neuhaus of the Free University Berlin, and sent to us by his kind permission to use for our investigation. Clinical coronary angiographies were performed by Seldinger's method on 28 cases and 50 exposures were made. By using electronically controled X-ray apparatus, the injection was made at the end of systole under the pressure of 14kg./cm2., and exposure was made just before the systole of the second beat from the injection. We used 80% Angioconray as contrast medium. Eighty-five preliminary experiments on dogs using same method showed no serious complication. We experienced no direct serious complication on clinical trials of 50 times except for one case of femoral thrombosis.Results; 1. Grade of coronary sclerosis evaluated from the angiographic films of autopsy materials showed good correlations with histological findings of the coronary arteries of the respective parts, and with grade of histopathological changes in respective myocardium.2. Almost all the hearts which showed fine appearance of small arteries in the left ventricular myocardium on the ultrasoft X ray films corresponded to the ECG findings of left ventricular hypertrophy.3. About a half of cases whose angiograms revealed moderate grade of sclerosis showed normal ECG. Almost all the cases of normal angiographic appearance had normal ECG. All the cases of myocardial infarction showed severe sclerosis on
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