International audienceRegarded as biofunctional poly- and oligomers having much higher potential than cellulose in many fields, chitosan and its derivatives have become of great interest thanks to the recent progress in chitin chemistry. Chitosan, which is a natural-based polymer obtained by alkaline deacetylation of chitin, is an interesting bioactive polysaccharide composed of many reactive groups. This gives huge possibilities of chemical modifications to create new derivatives with a broad range of physico-chemical and biological activities. This review gives insights into chitosan, chitosan derivatives and their biological activities. Recent progresses of their chemistry are also discussed as well as biodegradability and environmental assessment concepts applied to these derivatives
The present study is focused on the effect of chitin derivatives against human cancer cell lines RD and Hep2. As an outcome from this research, chitin was cytotoxic at IC50 = 400 μg/ml and 200 μg/ml against Hep2 cells and RD cells lines, respectively. Irradiated chitin had an IC50 value of 450 μg/ml for Hep2 and an IC50 of 200 μg/ml for RD. The lowest IC50 is attributed to chitosan, 300 μg/ml in Hep2 and 190 μg/ml in RD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.