Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation increases in frequency, the need to evaluate the long-term storage stability of exhaled breath VOCs on thermal desorption adsorbent material is critical. To address this gap, exhaled breath was loaded on Tenax TA thermal desorption tubes and stored at various temperature conditions. 74 VOCs, 56 of which have been previously uncharacterized, were monitored using GC-MS over a period of 31 d. The results suggest that storage of exhaled breath at cold temperatures (4 °C) provides the most consistent retention of exhaled breath VOCs temporally. Samples were determined to be stable up to 14 d across storage conditions prior to gaining or losing 1-2 standard deviations in abundance. Through gene set enrichment analysis (GSEA), certain chemical classes were found to be positively (acids) or negatively (sulfur-containing) enriched temporally. By means of field sample collections, the effect of storage and shipping was found to be similar to those studies preformed in the laboratory at 4 °C. Collectively this study not only provides recommendations for proper storage conditions and storage length, but also illustrates the use of GSEA to exhaled breath based GC-MS data.

Although the law assumes a close relation between the probability that a defendant committed the act in question and the ensuing verdict of the jurors, prior research has shown this assumption to be often violated. We present five experiments designed to show that factors that influence probability also influence verdict, but other factors are capable of directly producing changes in verdict without affecting probability. In Experiment 1, we replicated the Wells Effect; scenarios generating the same probability that the Blue Bus Company was to blame for the same accident, nevertheless, generated significantly different likelihoods of finding the defendant liable. In Experiment 2, we showed that equally diagnostic affirmative and negative evidence had differential effects on mock jurors' probability estimates and verdicts. In Experiment 3, we showed that a completely nondiagnostic witness, who either implicates the same bus company or a different bus company as did a diagnostic witness, significantly influenced mock jurors' verdicts. However, the nondiagnostic witness did not change the probability that the Blue Bus Company was responsible for the accident. In Experiment 4, we demonstrated that base rate and witness reliability information resulted in very similar probability estimates but radically different verdicts. In Experiment 5, we showed that a change in the diagnosticity of the evidence influenced both probability and verdict with the former mediating differences in the later. Because probability is only one of the several determinants of the verdict, the two dependent variables are not as closely related as the law presumes.

A major proportion of aircraft pilots may participate in healthcare avoidance behavior due to fear of aeromedical certificate loss. This may result in delayed or limited medical care in pilots with new or chronic medical conditions.