Additive‐free: The chemoselective amide‐bond‐forming ligation between N‐alkylhydroxylamines and α‐ketoacids requires no reagents and the only by‐products are water and carbon dioxide. This process proceeds on unprotected peptide substrates without epimerization, and as such, this process has the potential to serve as a novel chemoselective ligation for the synthesis of peptides and complex materials.
Ganz ohne Additiv: Die chemoselektive Ligation zwischen N‐Alkylhydroxylaminen und α‐Ketosäuren unter Bildung einer Amidbindung erfordert keine Reagentien und hat als einzige Begleitprodukte Wasser und Kohlendioxid. Nicht geschützte Peptidsubstrate werden dabei nicht epimerisiert, was dem Prozess Potenzial als neuartige chemoselektive Ligation zur Synthese von Peptiden und komplexen Materialien verleiht.
Carbohydrates U 0500 Total Synthesis of Two Naturally Occurring Polyacetylenic Glucosides (-)-Bidensyneoside A1 (Ia) and B (Ib), and an Analogue (Ic) of (-)-Bidensyneoside C (Id). -(GUNG*, B. W.; FOX, R. M.; FALCONER, R.; SHISSLER, D.; Tetrahedron: Asymmetry 17 (2006) 1, 40-46; Dep. Chem. Biochem., Miami Univ., Oxford, OH 45056, USA; Eng.) -Y. Steudel 24-191
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