The recent trends in the synthesis of functional poly(ester)s by ring-opening polymerization (ROP) are reviewed. While the use of ROP processes for the synthesis of poly(lactide), poly(lactide-co-glycolide) and several poly(lactone)s has been well studied, the paucity of functional groups available for further reaction limits their application. Recent efforts to expand this available functionality are reviewed focusing on the application of renewable resources in the synthesis of new monomers and the utilization of click chemistry to provide common intermediate polymers in the manipulation of poly(ester) functionality. In turn these advances are leading to a new generation of precisely controlled nanoparticles comprised entirely of poly(ester)s.
The stoichiometric reaction between thiols and maleimide-functional poly(ester)s is demonstrated to be a quantitative, tolerant, mild and efficient method for polymer modification.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.