The coordination chemistry of Co(ii) with the chelating dicarboxylate ligand esp (esp = α,α,α',α'-tetramethyl-1,3-benzenedipropionate) is explored. We report here the bimetallic paddlewheel-type dimer, Co2(esp)2(EtOH)2 (1), and a bowl-shaped, heptanuclear coordination cluster, Co7(OH)4(Hesp)2(esp)4(MeCN)2·4MeCN (2). Crystal structures of both complexes are reported as well as their magnetic properties, which indicate antiferromagnetic interactions among the Co(ii) ions.

Palladium(II) acetate (1) and two new complexes of the ligand α,α,α',α'-tetramethyl-1,3-benzenedipropionate (esp), C -Pd(esp) ( C-2) and C-Pd(esp) ( C-2), are studied in the solid state and in solution. Variable-temperature NMR and DFT studies of C -2 reveal an unusual shielding region above the Pd atoms. The compounds show a surprising quasi-reversible reduction between -880 and -1200 mV versus Fc/Fc, and the Pd(esp) complexes may be cleanly reduced electrochemically. EPR spectra of reduced samples show pseudo-axial signals with Pd hyperfine coupling, consistent with unprecedented, isostructural Pd species with a valence-trapped Pd-Pd-Pd electronic structure.

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Positron emission tomography (PET) is a powerful tool in medicine and drug development, allowing for non‐invasive imaging and quantitation of biological processes in live organisms. Targets are often probed with small molecules, but antibody‐based PET is expanding because of many benefits, including ease of design of new antibodies toward targets, as well as the very strong affinities that can be expected. Application of antibodies to PET imaging of targets in the central nervous system (CNS) is a particularly nascent field, but one with tremendous potential. In this review, we discuss the growth of PET in imaging of CNS targets, present the promises and progress in antibody‐based CNS PET, explore challenges faced by the field, and discuss questions that this promising approach will need to answer moving forward for imaging and perhaps even radiotherapy.

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