A novel route of one-pot multicomponent reaction of tosylates, aryl aldehydes and thiosemicarbazide for the synthesis of hydrazinyl thiazole is reported using Fe2O3 NPs derived from rust iron as a catalyst.
Sulfonylureas is being used throughout the world for the treatment of diabetes mellitus. The aim of the present study was to investigate mode of action of tosylacrylimidamide. Tosylacrylimidamide a non-classical bioisosteres of sulfonyl urea, bioisosteres refer to structurally distinct molecules eliciting a similar biological effect. In the present study we have determined the ability of tosylacrylimidamide to stimulate insulin secretion from MIN-6 cells. The compounds were tested in the presence of 5 mM glucose concentration, our results indicates that compound 4 e, 4 f, 4 g were the most effective insulin secretagogue's amongst reported, then 4 e, 4 f, 4 g were further evaluated at various concentration of compound keeping glucose concentration constant (5 mM), resulting 4 e showed 4.34 fold increase in insulin secretion at 1 mg/ml of compound, 4 f showed 7.4 fold increase in insulin secretion at 5 mg/ml of compound and 4 g has shown 7.6 fold increase in insulin secretion at 5 mg/ml of compound. The rest of the tosylacrylimidamide in our assay had only marginal effects on insulin secretion[a] S.
The current manuscript elucidates Ficus benghalensis (F.B.) leaf extract‐mediated green synthesis of Fe3O4 nanoparticles as magnetic support for the synthesis of novel Fe3O4@Ag‐S‐CH2‐COOH magnetic nanocomposite. The structure of Fe3O4@Ag‐S‐CH2‐COOH is confirmed by various characterization techniques such as FT‐IR, XRD, SEM, HR‐TEM, BET, and VSM analyses. Catalytic potential of Fe3O4@Ag‐S‐CH2‐COOH was tested for the syntheses of novel 3,4‐dihydropyrimidin‐2(1H)‐ones through one‐pot Biginelli reaction of aryl aldehydes, urea, and avobenzone. The Fe3O4@Ag‐S‐CH2‐COOH exhibited outstanding catalytic activity towards Biginelli reaction and could be easily separated from the reaction mixture by an external magnet. Interestingly, catalyst could be recycled for four successive turns without considerable loss in the catalytic activity. The structure of novel 3,4‐dihydropyrimidin‐2(1H)‐ones were confirmed by FT‐IR, 1H, 13C‐NMR, mass spectrometry, and single crystal X‐ray diffraction technique. Synthesized novel 3,4‐dihydropyrimidin‐2(1H)‐ones were tested for anti‐cancer activity against human liver cancer cell line Hep‐G2 along with anti‐angiogenesis study and confirmed by molecular docking investigations.
In the present work, Ficus benghalensis leaf extract was used for the synthesis of ZrO2 nanoparticles. Further, ZrO2@Ag‐S‐CH2‐COOH was synthesized using biosynthesized ZrO2, and its catalytic potential was examined in the synthesis of pyrazoline from reaction of chalcone and hydrazine hydrate at room temperature. The structural conformation of ZrO2@Ag‐S‐CH2‐COOH has been done using FT‐IR, SEM, EDX, XRD, TGA‐TDA, XPS, and DLS techniques, high turnover number (TON), and high turnover frequency. The ZrO2@Ag‐S‐CH2‐COOH demonstrated outstanding catalytic activity for the synthesis of pyrazolines. The structures of the pyrazoline derivatives were confirmed by FT‐IR, 1H and 13C NMR, and mass spectrometry techniques. Synthesized pyrazoline were tested for anticancer activity against human lung cancer cell line A549 study and confirmed by molecular docking investigations.
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