The COVID-19 pandemic has displayed new challenges for chemistry instructors and students worldwide. An essential part of learning chemistry involves interactions in a laboratory ambiance. However, nowadays, it is necessary to consider alternatives to teaching experimental chemistry in an online environment. As a course project proposal, the students produced homemade videos to investigate a specific topic and find alternative ways to transfer their knowledge through innovative pedagogical and communicational tools. This work was assigned to first-year undergraduate students in a Chemistry I course who could not access an on-campus laboratory. This activity was performed in eight lab sections, considering seven different lab assignments, with 56 homemade educational videos. Each course had an instructor who guided the students and gave their feedback to improve the video quality. The final video output was subjected to an evaluation process consisting of three steps: the instructors’ evaluation, pedagogical analysis, and communicational review. Making educational videos at home could be an excellent alternative to boost the transfer of chemistry knowledge through didactic and audiovisual resources that promote learning within the university, from home, and in remote environments.
3,4-Dihydro-2(1H)-pyridones (3,4-DHPo) and their derivatives are privileged structures, which has increased their relevance due to their biological activity in front of a broad range of targets, but especially for their importance as synthetic precursors of a variety of compounds with marked biological activity. Taking into account the large number of contributions published over the years regarding this kind of heterocycle, here, we presented a current view of 3,4-dihydro-2(1H)-pyridones (3,4-DHPo). The review includes general aspects such as those related to nomenclature, synthesis, and biological activity, but also highlights the importance of DHPos as building blocks of other relevant structures. Additional to the conventional multicomponent synthesis of the mentioned heterocycle, nonconventional procedures are revised, demonstrating the increasing efficiency and allowing reactions to be carried out in the absence of the solvent, becoming an important contribution to green chemistry. Biological activities of 3,4-DHPo, such as vasorelaxant, anti-HIV, antitumor, antibacterial, and antifungal, have demonstrated this heterocycle’s potential in medicinal chemistry.
3,4-Dihydro-2(1H)-pyridones (3,4-DHPo) and their derivatives are privileged structures present in natural products, which has been increased its relevance due to its biological activity in front of a broad range of targets, but especially for its importance as synthetic precursors of a variety of compounds with marked biological activity. Taking into account the large number of contributions published over the years regarding this kind of heterocycle, here we presented a current view of 3,4-dihydro-2(1H)-pyridones (3,4-DHPo), which include general aspects such as those related to nomenclature, synthesis, and biological activity; but also highlighting the importance of DHPo as building blocks of other relevance structures.
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