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These results demonstrate that various glucose-lowering therapies and oleic acid reduce resistin gene expression in isolated adipocytes, and that resistin impairs insulin-stimulated glucose uptake in skeletal muscle-derived cells.

The incidence of type 2 diabetes is increasing at an alarming rate; epidemiological studies indicate that by the year 2010 there will be 300 million people with type 2 diabetes worldwide. The rate of increase is highest in Asia and among young adults with obesity. On average, patients with diabetes live 5À10 years less than their non-diabetic counterparts, mainly because of accelerated atherosclerotic disease.A diagnosis of diabetes confers a two-to fourfold increased risk of intermittent claudication and a 10À16-fold increase in the lifetime risk of a lower limb amputation.

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