Purpose:The aim was to investigate multifocal electroretinogram (mfERG) findings in Bietti's crystalline dystrophy (BCD) using a retrospective, non-interventional, consecutive case series. Methods: Five patients, two women and three men (mean age 31.8 years), clinically diagnosed with BCD underwent full-field electroretinogram (ffERG) and mfERG using Burian Allen bipolar contact lens electrode on the VERIS Science 5.2.1X system. The ffERG and mfERG parameters of patients with Bietti's crystalline dystrophy were compared with age-matched normal subjects. The N1, P1 amplitudes and implicit times of the mfERG for the six concentric rings were analysed. Results: The ffERG showed significant decreases in the amplitude of the scotopic and photopic responses in all patients; however, implicit times were only mildly prolonged. Rod response implicit times appeared to be more affected than the cone responses. The N1 and P1 amplitudes of mfERG showed a significant decrease in all rings in all patients. N1 implicit times were significantly delayed in rings 3, 4 and 5. The P1 implicit time was significantly delayed in all rings except 1 and 6. Conclusion: The mfERG in Bietti's crystalline dystrophy can provide insight into the functional retina and objectively help to quantify the extent of retinal damage.
Purpose: To study the clinical and microbiological profile, treatment modalities, and anatomical and functional outcomes among children and adolescents with endogenous endophthalmitis (EE) at a tertiary eye care centre in India. Methods: Medical records of subjects <18 years, presenting with EE from 1997 to 2007 were reviewed. Cases where the causative organism was identified were included. Treatment regimen included systemic antibiotics, vitrectomy, intravitreal antibiotics, and enucleation. Systemic evaluation to identify the source of infection was done by an internist. Microbiological analysis of blood, urine, and ocular specimens was done. The favorable anatomical outcome was defined as the attached retina, with controlled intraocular pressure and clear media at the last follow up. The favorable functional outcome was defined as vision >3/60 on the final follow up. Univariate regression analysis was done to identify factors predicting functional outcome. Results: Thirty eyes of 30 subjects (23 (77%) males) were studied. The mean age at presentation was 6.8 years (range=1–16 years). Fever was evident in four (13%) and blood culture was negative in all cases. Gram-positive organisms were identified in 11 (37%) eyes, fungi in 3 (10%), and toxocara in 8 (27%) eyes. Twenty-three (77%) eyes underwent vitrectomy. Favorable functional and anatomical outcomes were achieved in 9 (30%) and 12 (40%) eyes, respectively. Eyes undergoing vitrectomy showed significant correlation with good functional outcome ( P = 0.05). Conclusion: EE is under-reported and not well studied in children. The absence of systemic features may be evident in a developing country with over the counter availability of antibiotics. Gram-positive infections are common and vitrectomy is a beneficial modality of treatment.
Vitreoretinal surgery in eyes with Pintucci biointegrable keratoprosthesis is a highly challenging situation that requires intricate planning and an integrated approach. However, it can result in good anatomical and functional outcomes.
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