Workers with chronic benzene poisoning (CBP) sometimes have a white blood cell count (WBC) below 4 x 10(9)/L even after cessation of workplace exposure to benzene for years. In order to explore this phenomenon, 120 workers with CBP were divided into two groups depending on the WBC, the mean diagnostic age of CBP, benzene exposure duration, and body mass index (BMI). The proportion of genotypes of cytochrome P450 2E1 (CYP2E1), glutathione-S-transferase mu-1 (GSTM1), glutathione-S-transferase theta-1 (GSTT1), myeloperoxidase (MPO), and NAD(P)H, quinone oxidoreductase 1 (NQO1) were compared between workers with WBC <4 x 10(9)/L and those with WBC > or =4 x 10(9)/L. With methods of logistic regression, a risk model was set up to predict the prognosis of CBP workers. The results indicated that the BMI of workers with WBC <4 x 10(9)/L was lower than that of workers with WBC of > or =4 x 10(9)/L (21.40 +/- 2.76 versus 23.09 +/- 3.36, P = 0.01), and the logistic regression model suggested there was a 4.5-fold increased risk among workers carrying GSTT1 null genotype (95% CI= 1.13- 17.54) compared with workers with GSTT1 non-null genotype. Our findings suggest that benzene exposure duration, BMI, and GSTT1 genotype may impact prognosis of the CBP workers.
Objective: Many drugs can cause drug-induced lung injury (DLI), but its clinical features and pathogenic factors are not fully clear. The present study aims to explore the clinical characteristics and related risk factors of DLI and to provide a reference for the safe application of the drug. Materials and Methods: The clinical features of patients diagnosed with DLI in our hospital between 2014 and 2018 were retrospectively analyzed. DLI was diagnosed by using the Japanese Respiratory Society criteria. A retrospective case-control study was conducted according to suspected drugs, race, and significant diagnosis-matched controls, and logistic regression was used to identify risk factors. Results: 38 patients were diagnosed with DLI, and the median time from initiation of medication to the diagnosis of DLI was 74 days. The main clinical symptoms were shortness of breath (81.6%), cough (71.1%), expectoration (55.3%), and fever (42.1%); chest CT showed mainly ground glass opacity (GGO) (81.6%), nodular pattern (36.8%), increased of lung markings (34.2%) and interlobular septal thickening (23.7%). In laboratory tests, the levels of WBC, ALT, LDH, CRP, and KL-6 were significantly increased, while creatinine and albumin levels were significantly decreased. A total of 32 patients were treated with steroids. Of all the 38 patients, six were utterly cured, 27 showed improvement in their symptoms, two were poorly treated, and three died; In the matched case-control study, 38 DLI patients were successfully matched with 152 non-DLI controls. After multifactorial analysis, no factors were significantly associated with an increased incidence of DLI. Conclusions: The prognosis of DLI is poor, so it is necessary to be highly vigilant when using drugs that are easy to induce DLI. LDH and KL-6 may be useful biomarkers related to DLI. No significant risk factors for DLI were found in the present study, further high-quality original studies are needed to draw definitive conclusions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.