A new simple, specific, precise and accurate reversed-phase liquid chromatography method has been developed for simultaneous estimation of Drotaverine HCl (DRO) and Nimesulide (NIM) in tablet formulation. The separation was achieved on a 5-micron C18 column (250 X 4.6 mm) using mobile phase consisting of a mixture of water: acetonitrile: methanol 30: 35: 35 % (pH 2.5, adjusted with orthophosphoric acid). The flow rate was maintained at 1.0 ml/min, with an average operating pressure of 2630 psi. The detection of the constituents was done using UV detector at 295 nm for DRO and NIM. The retention time of DRO and NIM were approximately 5.6 and 10.6 min respectively. Recovery study values of DRO and NIM is 100.06+0.40 and 100.13+0.34 respectively, relative standard deviation of less than 2% for the assay show that the method is precise, accurate and linear in the concentration given and demonstrate the method developed is rugged and robust. Linear response obtained for DRO was in the concentration range 50-250 µg/ml and NIM in the range 125-625 µg/ml.
Narail Sadar Upazilla is a major agricultural productive region of Narail District, Bangladesh. The crop production here significantly depends on the Chitra River water for irrigation. The present study was undertaken with an aim to evaluate the usability of this river water for irrigation purpose during pre-monsoon, monsoon and post-monsoon. Sampling was conducted three times in each season both in high tide and low tide. The collected samples were analyzed for some physicochemical parameters including pH, electrical conductivity (EC), total dissolved solid (TDS), major cations (Na + , K + , Ca 2+ and Mg 2+ ) and major anions (The calculated chemical indices' values for the collected water samples during pre-monsoon indicate that this river water is chemically suitable for irrigation during pre-monsoon with respect to sodium adsorption ratio (SAR), residual sodium carbonate (RSC) and permeability index (PI). The values of all chemical indices declare this river water fitness for use in irrigation both in monsoon and post-monsoon. According to Wilcox diagram, all of the water samples irrespective of tide and sampling stations fall within "permissible to doubtful" category during pre-monsoon while the water samples collected in both tide from all stations fall within "excellent to good" category during monsoon and post-monsoon. The United States Salinity Laboratory (USSL) diagram certifies this river water as C1-S1 (low salinity along with low sodium level) type during monsoon and post-monsoon which makes the river water suitable for use in irrigation in these two seasons while the water is mostly C3-S1, C3-S2 and C3-S3 (high salinity along with low to high sodium level) type in pre-monsoon which makes the river water restricted for use in irrigation in this season.
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