Primary familial brain calcification (PFBC) is a rare inheritable neurodegenerative disease mainly characterized by symmetrical calcification in the basal ganglia, thalamus, cerebellum, and brainstem (Wang et al., 2012). Patients with PFBC may experience movement disorders, cognitive impairment, psychiatric signs, or other associated manifestations with diverse severity and variable onset age or may be asymptomatic throughout their lives (Nicolas et al., 2015;Wang et al., 2015).PFBC can be transmitted in an autosomal dominant or recessive manner. PFBC causative genes identified to date
Background:Lobed kudzuvine root and rhizoma chuanxiong are effective drugs in traditional Chinese medicine.Objective:Extracts of the two medicines were investigated for their in vitro of beta-amyloid (Aβ1-42)-aggregation-and acetylcholinesterase (AChE)-inhibitory activities.Materials and Methods:The interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42) were studied by Michaelis–Menten equations, Thioflavin T (ThT) fluorescence analysis and transmission electron microscope (TEM).Results:Inhibition of acetylcholinesterase showed that 1-butanol fraction of the two medicines were noncompetitive inhibition, apparent inhibition constants were 9.947 and 7.1523. ThT fluorescence analysis and TEM results indicated that inhibition of the water fraction and 1-butanol fraction (both lobed kudzuvine root and rhizoma chuanxiong) was better.Conclusion:The result supported further research on chemical constituents and pharmacological mechanisms.
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