Background
To minimize drug‐related toxicity and monitor dosing regimens, an ultra‐sensitive, simple and high‐throughput analytical method for therapeutic drug monitoring is required. A novel LC–MS/MS bioassay of levetiracetam, lamotrigine and 10‐hydroxycarbazepine in human plasma was established. The analytes were separated on a Hypersil GOLD™ C18 column under a 2.5 min isocratic elution after one‐step protein precipitation. MS detection was performed under electrospray ionization positive‐mode fitted with selected reaction monitoring. The validated ranges were 0.1–20 μg/ml for LTG, 0.3–60 μg/ml for 10‐hydroxycarbazepine and levetiracetam. The intra‐ and inter‐batches of precision and accuracy was within ±15%. The novel method met all other criteria. Conclusion: This method can be used to monitor drug concentrations and decision‐making in epileptic patients.
Lithium-sulfur batteries have been deemed as one of the most promising energy storage systems for the next-generation batteries. However, some serious challenges hinder the commercialization, such as the shuttle effect of polysulfides and sluggish redox kinetics. Herein, novel FeP/spongy carbon (SC) composites with multiple adsorptions and catalytic sites are prepared as a modified separator. Specifically, the SC proves the structural stability and long ions/electron transmission channel. The adding of FeP can spontaneously react with polysulfides to block the shuttling and catalyze the conversion of sulfur chemistry. The formed adsorption-diffu-sion-conversion surface is beneficial to reduce the polarization and accelerate the redox kinetics. Furthermore, the FeP/SC modified separator can bring down the flammability to prove high-safety LSBs. Benefiting from these features, the assembled cells with FeP/SC exhibits extraordinary cycling stability (526 mAh g À 1 over 400 cycles at 1 C), a superior rate property with 619 mAh g À 1 at 2 C. Moreover, the cells with a high areal sulfur loading of 4 mg cm À 2 can maintain a capacity of 618 mAh g À 1 after 150 cycles. Such a FeP/SC modified separator provides a potential commercial application for high-safety and advanced Lithium-sulfur batteries.
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