The flow and heat transfer characteristics in micro-tube are very important research fields. In order to study the influence of the Reynolds number on the overall characteristics of flow and heat transfer, a 510 mm long micro-tube with dimples was constructed. Thirty-five different working conditions are considered, and the Reynolds number is between 1500 and 8100. At the same time, the change of physical properties of coolant with temperature is considered. The reliability of numerical simulation results is verified by the grid independence verification and the comparison of experimental data. The results show that the dimple will promote the instability of the flow state and improve the heat transfer efficiency. The flow state evolution formed in the stream-wise direction is basically similar, and its fully developed position remains at 76 mm, which is independent of the Reynolds number. For the fully developed region, the partial derivation of static pressure in the stream-wise component has a quasi-linear relationship with the stream-wise direction. With the development in the stream-wise direction, the partial derivation of static temperature in the steam-wise component decreases. With the increase of Reynolds number, the friction factor f and heat transfer factor j decrease. The ratio of factor heat transfer f to Reynolds number relative collapses for the different cases, especially when the Reynolds number is larger than 3800. The heat transfer factor j is an exponential function of the Reynolds number and decreases with the increased Reynolds number.
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