A new synthetic methodology has been developed to prepare the biologically important azepino[4,5-b]indole derivatives under Brønsted acid catalysis. The notable features of this protocol include its operational simplicity, high reaction yields and environmentally benign and mild reaction conditions.
A sequential one-pot approach to the tetrasubstituted 2H-imidazole scaffolds has been developed from disubstituted alkynes and structurally diverse ketones. The reaction proceeds via a diketo intermediate generated from internal alkynes followed by the addition of ammonium acetate and a suitable ketone, affording a diverse range of 2H-imidazoles. Using air-moisture stable reaction conditions and inexpensive reagents, the transformation demonstrates a broad substrate scope and good functional group compatibility.Scheme 1 Our previous and present studies.
Ap alladium-catalyzed domino strategy has been developed for the synthesis of 2,3-disubstituted benzofuran derivatives.T his cascade reaction sequence involves intermolecular carbopalladation and C(sp 3 ) À Hf unctionalization followed by isomerization.
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