Fungi and bacteria are a great threat to all living organisms by causing illnesses in them. Rate of spreading diseases by them is higher in contrast to synthesis of drugs that are antifungal and/or antibacterial 1-4. At present substantial part of the research in chemistry is devoted to the synthesis and characterization of biologically active compounds that would be used against the microbes 5-16. Monoesters of succinic acid, in addition to their chemical uses, possess medicinal properties like, antiHIV, antitumor, antiseptic, antioxidant, antifungal and antibacterial 10-16 activities. In continuation to our work to establish medicinal use of monoesters 17-20 twentyseven (1-27) new monoesters were prepared from succinic anhydride 7 and explored for antifungal and antibacterial activity. All the reported compounds displayed considerable bioactivities. However, the halogenated esters displayed activity equivalent to standard drugs chloramphenicol and ketoconazole. EXPERIMENTAL The microbes used for bioactivities of synthesized compounds (1-27) were Candida albicans ATCC 10231 (C. albicans), Aspergillus niger F2723 (A. niger), Escherichia coli MTCC-739 (E. coli) and Proteus mirabilis ATCC 14153 (P. mirabilis). Ketoconazole purchased from M/s SMS Pharmaceuticals Ltd. Hyderabad and chloramphenicol from Sigma St. Louis, USA was used as standard.
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