Finding neurobiological markers for neurodevelopmental disorders, such as attention deficit and hyperactivity disorder (ADHD), is a major objective of clinicians and neuroscientists. We examined if functional Magnetic Resonance Imaging (fMRI) data from a few distinct visuospatial working memory (VSWM) tasks enables accurately detecting cases with ADHD. We tested 20 boys with ADHD combined type and 20 typically developed (TD) boys in four VSWM tasks that differed in feedback availability (feedback, no-feedback) and reward size (large, small). We used a multimodal analysis based on brain activity in 16 regions of interest, significantly activated or deactivated in the four VSWM tasks (based on the entire participants' sample). Dimensionality of the data was reduced into 10 principal components that were used as the input variables to a logistic regression classifier. fMRI data from the four VSWM tasks enabled a classification accuracy of 92.5%, with high predicted ADHD probability values for most clinical cases, and low predicted ADHD probabilities for most TDs. This accuracy level was higher than those achieved by using the fMRI data of any single task, or the respective behavioral data. This indicates that task-based fMRI data acquired while participants perform a few distinct VSWM tasks enables improved detection of clinical cases.
There are conflicting results as to whether preschool children categorize artifacts on the basis of physical or functional similarity. The present study investigated the effect of the relative distinctiveness of these dimensions in children's categorization. In a physical-distinctive condition, preschool children and adults were initially asked to categorize computer-animated artifacts whose physical appearances were more distinctive than their functions. In a function-distinctive condition, the functional dimension of objects was more distinctive than their physical appearances. Both conditions included a second stage of categorization in which both dimensions were equally distinctive. Participants in a control condition performed only this stage of categorization. Adults in all conditions and stages consistently categorized by functional similarity. In contrast, children's categorization was affected by the relative distinctiveness of the dimensions. Children may not have a priori specific beliefs about how to categorize novel artifacts, and thus may be more susceptible to contextual factors.
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