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LEV was well tolerated in this elderly population in terms of cognition, mood, and balance. When anticonvulsant medication is indicated for older adults, LEV has pharmacokinetic advantages, and these data indicate no adverse impact on cognition or balance.

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Loneliness is a rising global problem just as digital communication platforms have afforded people greater opportunities to interact. This paradox suggests that increased opportunities for social interactions may be insufficient for relieving loneliness. Using daily diary methodology, we examined how features of social interactions—type and perceived quality—predicted daily loneliness. Over 14 consecutive days, 269 adult participants provided 2986 daily reports on their loneliness levels, the types of daily social interactions they had, and the quality of these social interactions. Results indicated that in-person interactions most strongly predicted reduced loneliness relative to other interaction types. Interactions characterized by positive qualities were associated with lower same-day loneliness. In turn, interactions characterized by negative qualities were associated with higher same-day loneliness. Across all subjective qualities, feeling closed off and distant from others during interactions was the strongest predictor of same-day loneliness. These findings highlight that time spent socializing is not a panacea for reducing loneliness, and increasing in-person interactions and reducing negative social experiences may best foster social connection.

Optimal functioning after psychopathology is understudied. We report the prevalence of optimal well-being (OWB) following recovery after depression, suicidal ideation, generalized anxiety disorder, bipolar disorder, and substance use disorders. Using a national Canadian sample ( N = 23,491), we operationalized OWB as absence of 12-month psychopathology, coupled with scoring above the 25th national percentile on psychological well-being and below the 25th percentile on disability measures. Compared with 24.1% of participants without a history of psychopathology, 9.8% of participants with a lifetime history of psychopathology met OWB. Adults with a history of substance use disorders (10.2%) and depression (7.1%) were the most likely to report OWB. Persons with anxiety (5.7%), suicidal ideation (5.0%), bipolar I (3.3%), and bipolar II (3.2%) were less likely to report OWB. Having a lifetime history of just one disorder increased the odds of OWB by a factor of 4.2 relative to having a lifetime history of multiple disorders. Although psychopathology substantially reduces the probability of OWB, many individuals with psychopathology attain OWB.

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