No abstract

No abstract

This work demonstrates the principle of a novel cancer therapeutic method using magnetic fluids to block the blood supply to a tumor in order to starve it. Plastic tubes are used to simulate the simplest blood network. The sealing effect to the fluid flow is easily achieved at low particle concentrations with strong pressure resistance and reasonable sealing times at low flow rate (Q = 0.078 ml/min). At high flow rate (Q > 0.62 ml/min), oscillations in pressure and step increases in weight of the fluid are found.

Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.