Titanium dioxide nanaoparticles (TiO 2 NPs) were prepared using laser ablation technique by ablation of titanium target immersed in distilled de-ionized water (DDW) by Q-switched pulsed Nd:YAG laser of 1064 nm, 1 Hz, ( 490) mJ and 700 pulse. UV-visible spectrophotometer and Transmission Electron Microscopy (TEM) were used to characterize the optical and morphological properties of prepared nanoparticles, respectively. The absorption spectrum of TiO 2 NPs was at ultraviolet-region (214 nm) due to Surface Plasmon Resonance (SPR), and the particles size distribution of the prepared nanoparticles ranged from 30 to 100 nm. The antifungal activity of TiOR 2 R NPs was carried out against Microsporum canis. TiOR 2 R NPs showed significant inhibitory activity especially at high concentrations and high exposure times with microbial pathogenesis.
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