Aims-The recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an infectious agent. This study aimed to address when and how HHV8 evolved. Methods-A cohort of African endemic KS (49 samples from 45 patients) and European KS (18 samples from 13 pa-Nuffield Department tients), spanning 27 years, was assessed of Pathology & for the presence of HHV8 by both stand-Bacteriology, ard solution phase polymerase chain reac-Oxford, United tion (PCR) and the newly described Kingdom technique of TaqMan PCR. M M Kennedy Results-HHV8 was present in approxi-E E Hanks mately 49% (24 of 49 tissue samples) of the J O'D McGee African cases and in more than 90% (16 of J J O'Leary 18 tissue samples) ofthe European cohort, Department of in keeping with recent seroepidemiologi-Pathology, UMDS, cal data.
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