ExtractFive hundred low birth weight children and 492 full-term infants were seen when approximately 40 weeks of age for a pediatric-neurologic examination. Of these, 822 provided the data upon which this report is based. To each child, when eight to ten years of age, there was administered ten subtests of the Wechsler Intelligence Test for Children (WISG), the Bender Gestalt Test and the Wide Range Reading and Spelling Achievement Test. In addition, observations were recorded regarding speech articulation and complexity of grammar. The number of perseveration instances and indications of possible comprehension aphasia observed during the examinations were recorded. The Verbal IQ_, Performance IO_ and Full Scale IO_ scores, as well as the independently obtained Bender Gestalt score, showed increasing impairment with decreasing birth weight. Approximately twice as large a proportion of low birth weight children as of control children fell into the IO_ category (50-79) which is associated with special medical or educational needs. At the ages of six to seven years the results of the Stanford-Binet Test showed an IQ, difference between the low birth weight and full-sized groups of 3.4 points (F = 7.77, 3 and 810 df, p < 0.001), whereas the WISG given at the ages of eight to ten years indicated an IO_ difference of 4.9 points (F = 10.87, 3 and 810 df, p < 0.001) for the same samples of children. Of the twenty psychological measures used to assess development of those who had been premature, relative impairment on 16 were significantly associated with birth weight and one was nearly so at the 0.05 level of significance. When the effect of the presence of indicators of possible neurologic abnormality was removed by analysis of covariance, the statistical significance of the association with birth weight was reduced for each of the variables measured, and only six of the twenty remained with significant assocation.
SpeculationFuture research might profitably consider whether performance by adolescents of low birth weight is relatively impaired in scholastic situations. Also, recent research suggests that a low birth weight occurring in conjunction with long gestational periods, may significantly prejudice intellectual capacity. However, there are little longitudinal data regarding this.
To investigate risk of stroke following use of oral contraceptives (OC) in less developed countries, a case-control study was conducted in Taiwan involving 323 cases hospitalized in 1978-1980, 250 hospital controls, and 646 neighborhood controls matched with cases on several variables. All were alive at interview. For the total sample, no increased risk was found. However, when comparison is with hospital controls, the risk for the recent OC users was increased (OR = 3.93, 95% C.L. 1.21, 5.46). This latter finding is consistent with studies in developed countries.
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