The electron-donating properties of the drug amiodarone (also known as cordarone), have been studied by conductimetry. Amiodarone was found to form a charge-transfer complex in vitro with the electron acceptor iodine, which is involved in human thyroid metabolism. Amiodarone was also found to interact with some other biological molecules with the capacity to behave as electron acceptors, such as dopamine hydrochloride, (-)-epinephrine, serotonin hydrochloride, coenzyme Qm and j9-nicotinamide adenine dinucleotide. An electronic absorption band in the visible region of the spectrum due to chargetransfer complex formation between iodine and amiodarone was also observed, supporting the conductimetric results.
The electron donating properties of the drugs, amiodarone, desethylamiodarone, promethazine and codeine have been studied using the electrochemical technique of conductivity titration, complemented by electronic absorption spectroscopy. All were found to form chargetransfer complexes in vitro with the electron acceptor iodine in acetonitrile. A quantitative explanation has been proposed to account for the observed temperature dependence of the conductivity. This is based on consideration of the opposing effects of charge mobility and the temperature-dependent donor-acceptor equilibrium. An assessment of the use of the hydrochloride form, instead of free base, of drugs in examining the model systems for the study of drug donor-acceptor interactions is also presented.
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