The addition of P(O)-H bonds to alkenes has been accomplished using microwave irradiation in the absence of added solvent and catalyst. In addition to single addition reactions, tandem hydrophosphinylation reactions with alkynes afforded unsymmetrical species such as phosphine oxide-phosphinates. [reaction: see text]
Organo-phosphorus compounds S 0080Microwave-Assisted Regioselective Addition of P(O)-H Bonds to Alkenes Without Added Solvent or Catalyst. -The reactions of the phosphine oxide (IIa) and phosphinate (IIb) with the variety of terminal alkenes proceeds smoothly. The desired products are formed in high yields, with the best results obtained when the alkene contains an activating group. In many cases, the crude products are >95% pure when removed from the microwave. Since the phosphorus center in (IIb) is chiral, the corresponding products are obtained as a mixture of diastereomers. -(STOCKLAND, R. A. J.; TAYLOR, R. I.; THOMPSON, L. E.; PATEL, P. B.; Org. Lett. 7 (2005) 5, 851-853; Dep. Chem., Bucknell Univ., Lewisburg, PA 17837, USA; Eng.) -R. Steudel 30-159
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