COAGULOPATHIES suggestive of disseminated intravascular coagulation are frequently observed in clinical septic shock. 3' 6, 8,14 Although there is no clear explanation of its cause, the disseminated intravascular coagulation (DIC) has usually been attributed to hypercoagulability of blood secondary to blood stasis and acidosis occurring in shock. Experimental studies have shown that alterations of hemostasis can be produced by injection of bacterial endotoxin into dogs 16 and rabbits.2 However, several authors have pointed out that primates respond differently to endotoxin shock than other mammalian orders.4'13. 8,27 Also, Guenter et al. have noted differences in the response of primates to live bacteria in contrast to bacterial endotoxin,9 although Thomas et al. did not find this to be the case.26 To make our results as applicable as possible to the clinical situation, we have studied the shock produced by administration of live bacteria in a primate species.
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