Anorexia is characterized by a decrease in appetite. One-third of patients on hemodialysis(HD) have anorexia, which is characterized as the lack of the urge to eat. We essentially don't know how the disease started. Leptin, ghrelin, neuropeptides, inflammation, altered amino acid pattern, and uremic toxins as intermediate molecules have all been proposed as potential contributing factors. Malnutrition and cachexia are both facilitated by anorexia, which lowers oral protein and energy intake. There is no doubt that it lowers life quality. It is debatable if anorexia has any clinical significance as astandal one prognostic factor in HD patients. The therapy approach used to treat this crippling ailment may include regular dialysis sessions and nutritional advice. By bringing plasma branched-chain amino acids back to normal with branched-chain amino acid supplementation, anorexia may be reduced and energy and protein intake may be increased... Megestrol acetate's ability to stimulate appetite has to be supported by sufficient randomized studies. Melanocortin-receptor antagonists and subcutaneous ghrelin injection seem like potential treatment approaches. The uremic syndrome frequently leads to eating and appetite issues, which worsen malnutrition in dialysis patients. According to the findings, uremic anorexia could without the development of visceral and abdominal fatless food consumption. this type of obesity is characterized by The prevalence of intake and malnutrition) is higher in dialysis patients. than obesity brought on by excessive eating.