Cellular radiosensitivity parameters of the track structure theory of Katz and coworkers are evaluated from a sum of squares minimizing computer program for nonlinear models. Based on these observations, suggestions are presented for efficient experiment design for the determination of these parameters from tracksegment bombardments of high LET radiations.
The boron-10 based Multi-Grid detector is being developed as an alternative to helium-3 based neutron detectors. At the European Spallation Source, the detector will be used for time-of-flight neutron spectroscopy at cold to thermal neutron energies. The objective of this work is to investigate fine time-and energyresolved effects of the Multi-Grid detector, down to a few µeV, while comparing it to the performance of a typical helium-3 tube. Furthermore, it is to characterize differences between the detector technologies in terms of internal scattering, as well as the time reconstruction of ∼ µs short neutron pulses. The data were taken at the Helmholtz Zentrum Berlin, where the Multi-Grid detector and a helium-3 tube were installed at the ESS test beamline, V20. Using a Fermi-chopper, the neutron beam of the reactor was chopped into a few tens of µs wide pulses before reaching the detector, located a few tens of cm downstream. The data of the measurements show an agreement between the derived and calculated neutron detection efficiency curve. The data also provide fine details on the effect of internal scattering, and how it can be reduced. For the first time, the chopper resolution was comparable to the timing resolution of the Multi-Grid detector. This allowed a detailed study of time-and energy resolved effects, as well as a comparison with a typical helium-3 tube.
An ad hoc model of energetic heavy ion beams, including secondary and tertiary particles, has been constructed for predicting radiobiological experiments. While the beam model is relatively primitive, it yields depth-dose and depth-radiobiological calculations in good agreement with experiment upstream of the Bragg peak. Beyond the peak, the model is somewhat coarse grained and seems to underestimate low-LET fragment production. These defects can be repaired at some cost in computer time. Presently a complete set of depth-dose and radiobiological results (RBE, OER, aerobic and hypoxic survival) is obtained in 4-8 min, for a single beam, at a cost of $10. The model can be extended to mixed radiation fields, or to explore the design of ridge filters. These predictions are based on cellular radiosensitivity parameters extracted from track-segment irradiations at about 8 MeV/amu. Their success implies that no new radiobiological results arise from irradiation with beams at 500 MeV/amu.
An ad hoc model of energetic heavy ion beams, including secondary and tertiary particles, has been constructed for predicting radiobiological experiments. While the beam model is relatively primitive, it yields depth-dose and depth-radiobiological calculations in good agreement with experiment upstream of the Bragg peak. Beyond the peak, the model is somewhat coarse grained and seems to underestimate low-LET fragment production. These defects can be repaired at some cost in computer time. Presently a complete set of depth-dose and radiobiological results (RBE, OER, aerobic and hypoxic survival) is obtained in 4-8 min, for a single beam, at a cost of $10. The model can be extended to mixed radiation fields, or to explore the design of ridge filters. These predictions are based on cellular radiosensitivity parameters extracted from track-segment irradiations at about 8 MeV/amu. Their success implies that no new radiobiological results arise from irradiation with beams at 500 MeV/amu.
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