Hyaluronic acid (HA) promotes wound healing, and, accordingly, formulations based on HA have been widely used in regenerative medicine. In addition, naturally derived compounds, e.g., plant-based extracts and vitamin E, have exhibited antioxidant activity. In this study, a formulation containing hyaluronic acid, vitamin E, raspberry extract, and green tea was developed for potential topical applications, targeting wound healing. Rheological analysis was performed along with antioxidant and biological studies. The rheological characterization showed that the HA-based formulation is a thixotropic platform and possesses higher mechanical properties than the control formulation. To evaluate the wound healing potential of the formulation, an in vitro “wound healing” assay was carried out using human derived fibroblasts (HDF) with a cell-free gap on the tissue culture dish. The formulation showed better wound healing ability than the control formulation.
Abstract:The paper describes a didactic experience that completes a project with a practical approach with the aim of sharing objectives and methodologies of two universities in different countries, and of testing new ways for design teaching. The university teaching is confronted increasingly with the requirement to put in contact the education to practice, at the same time, it is essential to integrate the teaching approaches of other realities and ask to students to share languages and tools with the aim to increase their skills and expertise for suitable solutions. The experience reported in the paper concerns a experimental shared teaching program, conducted on the nutrition topic, that helps students to management all phases of the project from the scenario definition to the exhibition of prototypes. The didactic experience, meant like knowledge-oriented approach to shared ways of life and belongings, prepares the theoretical tools to deal consciously strategic projects of local development.
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