Photodynamic therapy-generated ROS inactivates A. actinomycetemcomitans both in planktonic and biofilm cultures, even in small concentrations of the photosensitizing agent, and it does not cause damage to fibroblast cells under the same conditions.
PDT using MB or ERY as a photosensitizing agent and odontologic resin photopolymerizer as a light source could be an efficient option for pocket decontamination in aggressive periodontal disease.
Some filamentous fungi present the phenomenon of dimorphism, their morphological structure alterations being capable of inducing metabolism changes. The Aspergillus niger strain 10v10, a producer of citric acid, was submitted to the mutagenic action of ultraviolet irradiation which respectively selects mutants sensitive or resistant to the antifungi agent 5 fluorocytosine (5-FC). 5-FC sensitive mutants presented a morphological alteration to a yeast-like form. The effects of pH changes, addition of salts (KH 2 PO 4 , NH 4 NO 3 , MgSO4 and MgCl2), the presence of osmotic stabilizers, as well as of calcium chloride, on morphological reversal and acid production were studied. Morphological reversal to the filamentous form was observed only in the presence of CaCl 2 (500mM) for the mutants strains 1 and 2, while the acid production occurred in both, yeast-like and filamentous forms.
Primeiramente não poderia iniciar meus agradecimentos sem agradecer a DEUS, que me proporcionou mais essa conquista, que colocou as pessoas certas em meu caminho, me guardou me livrou e renovou a cada manha as suas misericórdias sobre a minha vida. Obrigada meu DEUS! Obrigada aos meus pais Luiz e Mary, por se fazerem presentes em todos os momentos de minha vida, que com amor, carinho e dedicação me fizeram ver o mundo como ele é e me incentivaram a procurar nele, o meu lugar. Agradeço a cada uma de minhas irmãs, Rosemary, Rosana, e Renata por fazerem parte da minha vida. Vocês são muito especiais para mim. Gustavo obrigado pelo incentivo, companheirismo, pelas palavras de animo pelos abraços que nos momentos difíceis, eram meu refugio. Aos companheiros e amigos de laboratório, que sempre ficarão na minha memória e no meu coração,
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