Background: Living at high altitude or with chronic hypoxia implies functional and morphological changes in the right ventricle and pulmonary vasculature with a 10% prevalence of high-altitude pulmonary hypertension (HAPH). The implications of working intermittently (day shifts) at high altitude (hypobaric hypoxia) over the long term are still not well-defined. The aim of this study was to evaluate the right cardiac circuit status along with potentially contributory metabolic variables and distinctive responses after long exposure to the latter condition.Methods: A cross-sectional study of 120 healthy miners working at an altitude of 4,400–4,800 m for over 5 years in 7-day commuting shifts was designed. Echocardiography was performed on day 2 at sea level. Additionally, biomedical and biochemical variables, Lake Louise scores (LLSs), sleep disturbances and physiological variables were measured at altitude and at sea level.Results: The population was 41.8 ± 0.7 years old, with an average of 14 ± 0.5 (range 5–29) years spent at altitude. Most subjects still suffered from mild to moderate symptoms of acute mountain sickness (mild was an LLS of 3–5 points, including cephalea; moderate was LLS of 6–10 points) (38.3%) at the end of day 1 of the shift. Echocardiography showed a 23% mean pulmonary artery pressure (mPAP) >25 mmHg, 9% HAPH (≥30 mmHg), 85% mild increase in right ventricle wall thickness (≥5 mm), 64% mild right ventricle dilation, low pulmonary vascular resistance (PVR) and fairly good ventricle performance. Asymmetric dimethylarginine (ADMA) (OR 8.84 (1.18–66.39); p < 0.05) and insulin (OR: 1.11 (1.02–1.20); p < 0.05) were associated with elevated mPAP and were defined as a cut-off. Interestingly, the correspondence analysis identified association patterns of several other variables (metabolic, labor, and biomedical) with higher mPAP.Conclusions: Working intermittently at high altitude involves a distinctive pattern. The most relevant and novel characteristics are a greater prevalence of elevated mPAP and HAPH than previously reported at chronic intermittent hypobaric hypoxia (CIHH), which is accompanied by subsequent morphological characteristics. These findings are associated with cardiometabolic factors (insulin and ADMA). However, the functional repercussions seem to be minor or negligible. This research contributes to our understanding and surveillance of this unique model of chronic intermittent high-altitude exposure.

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In southern European cities, research on deprivation and mortality inequalities using small-area analysis is recent. In many countries, the census tract (CT) is

Oxygen challenge imaging involves transient hyperoxia applied during deoxyhaemoglobin sensitive (T2*-weighted) magnetic resonance imaging and has the potential to detect changes in brain oxygen extraction. In order to develop optimal practical protocols for oxygen challenge imaging, we investigated the influence of oxygen concentration, cerebral blood flow change, pattern of oxygen administration and field strength on T2*-weighted signal. Eight healthy volunteers underwent multi-parametric magnetic resonance imaging including oxygen challenge imaging and arterial spin labelling using two oxygen concentrations (target FiO 2 of 100 and 60%) administered consecutively (two-stage challenge) at both 1.5T and 3T. There was a greater signal increase in grey matter compared to white matter during oxygen challenge (p < 0.002 at 3T, P < 0.0001 at 1.5T) and at FiO 2 ¼ 100% compared to FiO 2 ¼ 60% in grey matter at both field strengths (p < 0.02) and in white matter at 3Tonly (p ¼ 0.0314). Differences in the magnitude of signal change between 1.5T and 3T did not reach statistical significance. Reduction of T2*-weighted signal to below baseline, after hyperoxia withdrawal, confounded interpretation of two-stage oxygen challenge imaging. Reductions in cerebral blood flow did not obscure the T2*-weighted signal increases. In conclusion, the optimal protocol for further study should utilise target FiO 2 ¼ 100% during a single oxygen challenge. Imaging at both 1.5T and 3T is clinically feasible.

About 15-20% of patients with Hodgkin lymphoma (HL) treated with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy ± radiotherapy still die following relapse or progressive disease. The outcome might be influenced by gene polymorphisms influencing chemotherapy metabolism. We studied 126 patients with HL treated with the ABVD regimen. We analyzed glutathione S-transferases (GSTT1, GSTM1 and GSTP1), cytochromes P450 (CYP3A4 and CYP2D6), UGT1A1 and BLMH gene polymorphisms and their association with clinical and outcome variables. Patients with a GSTM1 genotype associated with extensive or ultrahigh activity had a probability of 93.8% to achieve a complete response, while the remainder of the patients had a probability of 82.3% (p = 0.04). This variable maintained its statistical significance in multivariate analysis (hazard ratio 3.7, 95% confidence interval 1-13, p = 0.05). Patients with an extensive or ultrahigh GSTM1 genotype had better prognostic factors than those with poor or intermediate genotypes (hemoglobin level, p = 0.003; serum albumin, p = 0.05; and International Prognostic Score, p = 0.038). Thus, in the treatment of HL, clinical determinants might be more relevant than the pharmacogenetic parameters analyzed to date.

Para citar este artículo utilice la siguiente referencia: Villena-Serrano, M.; Zagalaz-Sánchez, M.L.; Castro-López, R-; Cachón-Zagalaz, J. (2017 ResumenEl pádel es un deporte de reciente práctica en España. Su interés y gran afluencia social hacen necesaria la investigación desde diferentes áreas de la ciencia. En este trabajo se presenta una revisión bibliográfica de la base de datos TESEO con el objetivo de analizar en profundidad las tesis doctorales aceptadas como válidas por la comunidad universitaria española en el ámbito del pádel. Se recopila información y se analizan las características fisiológicas, técnicas, tácticas, psicológicas y sociológicas, así como las demandas específicas en el desarrollo de esta actividad. La revisión sistemática como método utilizado en este estudio se basa principalmente en la estrategia de búsqueda en la base de datos del Ministerio de Educación, Cultura y Deporte, en el que se han encontrado y revisado cuatro tesis doctorales relacionadas con este deporte. Como conclusión se aporta una síntesis de la información recopilada. Palabras clavePádel; revisión sistemática; TESEO.

One of the diseases that arouses increasing interest in the health field is the Muscle Dysmorphia (MD), which is why through this study will analyze your relationship with eating behavior disorders (ED) in athletes. The sample consisted of 154 athletes who routinely perform bodybuilding exercise, which were subjected to two self-administered test to measure your levels of muscle Dysmorphia (Adonis Complex) and their scores on ED test through the EDI-2. The results show statistically significant relationships (r = .47 p <.001) between the variable significant muscle Dysmorphia test many of TCA dimensions, a fact that confirms the link between both disorders. Also obtained through regression analysis TCA dimensions demonstrated predictors of the study variable, explaining them as a whole 28% of the variability of muscle Dysmorphia. ResumenUna de las patologías que despierta interés creciente en el campo de la salud es la Dismorfia Muscular (DM), es por ello que a través del presente estudio se analizará su relación con los Trastornos de la Conducta Alimentaria (TCA) en deportistas. La muestra estuvo compuesta por 154 deportistas que habitualmente realizan ejercicio de musculación, los cuales respondieron a dos test autoaplicados para medir sus niveles de síntomas de Dismorfia Muscular (Adonis Complex) así como sus puntuaciones en TCA a través del test EDI-2. Los resultados muestran relaciones estadísticamente significativas (r=.47 p<.001) entre la variable DM con numerosas dimensiones del test de TCA, hecho que ratifica la vinculación existente entre ambos trastornos. Igualmente obtuvimos a través de un análisis de regresión dimen-